First- and second-generation antipsychotic med- ication and cognitive processing in schizophrenia. Curr Psychiatry Rep (2005) 7(4):304-10. doi:10.1007/s11920-005-0085-5Weickert TW, Goldberg TE. First- and second-generation antipsychotic medication and cognitive processing in schizophrenia . Curr ...
We searched PubMed for clinical studies that compared first-generation antipsychotics (FGAs; search terms “first-generation antipsychotic”, “conventional antipsychotic”, and “classical antipsychotic”) with second-generation antipsychotics (SGAs, search terms “second-generation antipsychotic”, and “aty...
The aim of this study was to elucidate, whether shift from first generation antipsychotics (FGA) to olanzapine can affect health-related quality of life (HRQoL) of residually symptomatic schizophrenic outpatients.Patients were randomized to either olanzapine or to continuation on their FGA. The 15D-...
We found decreased whole-brain FA and AD in medication-naive FEP compared with controls. In patients, lower FA was correlated with longer DUP (r = 0.32; p = 0.03) and poorer subsequent response to antipsychotic treatment (r = 0.40; p = 0.01). Importantly, we found a significant mediation...
Akathisia (静坐不能): extrapyramidal side effect of antipsychotic medication characterized by restlessness and inability to sit or stand in one position. (U951) second-generation antipsychotic mechanism:block 5-HT2A (serotonin 2A receptor)and have lower binding affinity at dopamine D2 receptor sites...
Objective: The authors evaluated emotion perception in acutely ill patients experiencing a first episode of schizophrenia. They also investigated the effects of antipsychotic medication on emotion perception. Method: Tests of the ability to perceive and discriminate emotional expressions from the Penn Comput...
(d) Grubbs–Hoveyda second-generation 0.2 eq, DCE, microwave, 70 °C, 1 h. (e) TFA/TIPS/H2O 95/2.5/2.5%, rt, 2 h. Our first approach was to replace turn-inducing proline residues 7 and 10 by allylglycine residues to mediate cyclization. With the presence of these two proline ...
Chwa WJ, Tishler TA, Raymond C, Tran C, Anwar F, Villablanca JP et al (2020) Association between cortical volume and gray-white matter contrast with second generation antipsychotic medication exposure in first episode male schizophrenia patients. Schizophr Res 222:397–410 Article PubMed PubMed...
Other work suggests that antipsychotic medication, particularly second-generation antipsychotics, may exert a neuroprotective effect [19]. Studies in rodents have supported a neuroprotective effect of second-generation antipsychotics [20], which may arise through several candidate mechanisms, including neurogen...
Approximately 50 % of the patients (n = 38 of 77) were treated with antipsychotics at the time of sampling (medication information was missing for one patient]. The maximum number of days on antipsychotic treatment for these patients was 26 days, mean number of days was 9.6 ± 1.9 (mean ...