Correction: Patients with stage 3 compared to stage 4 liver fibrosis have lower frequency of and longer time to liver disease complications (PLoS One (2018) 13:5 (e0197117) DOI: 10.1371/journal.pone.0197117)doi:10.1371/journal.pone.0199402Page Axley...
Liver fibrosisis the first stage of liver scarring leading tocirrhosisand liver failure, and is generally caused by the expansion of smooth muscle α-actin (α-SMA)-expressingmyofibroblaststhrough activatedHSCs. In response toinjuries, the HSCs are activated and found to overexpress fibrosis-inducing...
In a phase III, randomized controlled trial, 966 patients with biopsy-confirmed NASH and liver fibrosis (stage F1B, F2 or F3) were randomly assigned to receive a once-daily dose of 80 mg resmetirom, 100 mg resmetirom or placebo for 52 weeks. Resolution of NASH with no worsening of...
Liver cirrhosis, a late stage of liver disease, contributes to the development of hyperdynamic circulation, electrophysiologic abnormalities, and systolic and diastolic dysfunction in a syndrome termed cirrhotic cardiomyopathy.1 There is an association between liver fibrosis and incident heart failure (HF...
And most rats in the two groups showed stage 3 or 4 liver fibrosis. The severity of the liver fibrosis was markedly milder in the AdNR4A2 (AdNR4A2 and DMN treated together) group than that in AdNC group or model groups with most indicating stage 2 liver fibrosis (Fig. 6a and ...
the common denominator in a variety of chronic diseases including idiopathic pulmonary fibrosis, liver cirrhosis, and ulcerative colitis, among others. These fibrotic diseases affect a vast number of people across the world significantly impacting the quality of their life and increasing health care ...
With liver biopsy as the gold standard, ROC curves were delineated for different endpoints. The area under the ROC curves reflected its diagnostic values. RESULTS: The distribution of their fibrosis stage was as follows, S0:3 (1.4%); S1:49 (23.1%); S2:66 (31.1%); S3:50 (23.6%); S4...
RESULTS: The Ishak stage scores of the livers in the control and 2, 4, 6-week groups increased when the TAA administration period was extended. L/H30 min increased with the upgrading of liver fibrosis and the differences between each pair of groups were statistically significant (p 30min in...
In each training stage of the four models, a large number of signal segments were extracted from the 150 sets and divided randomly into training and validation sets in a ratio of 80:20. Ten sets of RF data using the gold standard of quantitative fibrosis parameter (q-FP) of liver tissues...
It encompasses a spectrum of diseases, extending from nonalcoholic fatty liver (NAFL) through nonalcoholic steatohepatitis (NASH), advanced fibrosis to cirrhosis, and end-stage liver disease. The natural history of NAFL is variable, with the majority of individuals having benign disease with ...