Methods: We conducted a retrospective cohort study of adult patients with NASH cirrhosis (n= 1,338) who were evaluated in a single medical center between 2005 and 2015. Those who developed HCC were identified through electronic medical records using International Classification...
For example, liver fibrosis secondary to steatohepatitis could be an indicator of visceral adiposity and systemic inflammation, which are associated with HFpEF. Alternatively, liver injury could have a more integral role wherein cirrhosis drives systemic inflammation, endothelial dysfunction and HFpEF. We...
Dysfunction of the hepatobiliary system can occur when thickened secretions cause obstructions. Many patients with cystic fibrosis can present with hepatobiliary complications including fatty liver, cirrhosis, cholelithiasis, common bile duct stenosis, portal hypertension, and hepatic failure [68, 69]. ...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple steatosis to fibrosis remain poorly understood. Methods Gene...
Despite our increasing under- standing of cellular and molecular mechanisms contributing to liver fibrosis or cirrhosis, no anti-fibrotics are currently licensed for use in humans4,5. Activated hepatic stellate cells (HSCs or liver myofibroblasts) are the main effector cells involved in the ...
Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple steatosis to fibrosis remain poorly understood. Methods: Gene expression profiling using microarray, PCR array, and RNA sequencing was performed ...
Concerning CFLD, the association with Pa infection has been little studied; only one study suggested that cirrhosis may increase susceptibility to infection [45]. Besides, other variables such as socioeconomic status may change the exposure and course of Pa infection in pwCF. Although the French ...
Multivariate logistic regression evaluated predictors of 鈮 2 fibrosis or cirrhosis. Prevalence of fibrosis was stratified by U.S. Department of Health and Human Services geographic regions and compared with region-specific data on metabolic diseases and dietary patterns (fruit and vegetable intake) ...
Investigation has shown that patients with the active form of NAFLD, or called steatohepatitis (NASH), are probably coupled with fibrosis progression and eventually may result in cirrhosis [7]. CCl4 and retrorsine have been used to induce liver fibrosis/necrosis model in mice or rats [8–10]...
Keywords: liver fibrosis; matrinic; thiadiazole; structure-activity relationship; COL1A1; TGFβ/Smad pathway 1. Introduction Liver fibrosis is a general stage in the process of cirrhosis, which is characterized by the excessive accumulation of extracellular matrix (ECM) and abnormal hyperplasia of ...