CIRRHOSIS of the liverNOSOLOGYELECTRONIC health recordsBackground and aims: Identification of high-risk patients for hepatocellular carcinoma (HCC) is essential for long term monitoring of nonalcoholic steatohepatitis (NASH) cirrhosis progression. We sought to evaluate the association between ...
The miR-19 family plays a significant role not only in cardiac fibrosis but also in the development of fibrosis in tissues of lungs [27], liver [28], intestine [29], and kidneys [30]. One of the key mechanisms through which the miR-19 family influences fibrosis is through the PTEN gen...
scleroderma and liver fibrosis15,16. Furthermore, it could be demonstrated that XYLT1 expression is induced by TGF-β 1 in the early onset of OA cartilage repair, while XYLT1 expression is reduced by IL-1β in late stage OA. Therefore, XT is a central regulator of cartilage ...
1 There is an association between liver fibrosis and incident heart failure (HF).2 The mechanisms for this association, currently unclear, may be of particular importance for people living with human immunodeficiency virus (HIV) and/or hepatitis C, both of which are chronic infections with ...
Fabry disease is a rare X-linked hereditary disease caused by mutations in the AGAL gene encoding the lysosomal enzyme alpha-galactosidase A. Enzyme replacement therapy (ERT) is the current cornerstone of Fabry disease management. Involvement of kidney,
Nonalcoholic fatty liver disease (NAFLD) is a prevalent complication of extreme obesity. Loading of the liver with fat can progress to inflammation and fibrosis including cirrhosis. The molecular factors involved in the progression from simple steatosis to fibrosis remain poorly understood. Methods Gene...
the risk of OSF, which is widely recognized as an oral precancerous lesion or a potentially malignant oral disorder. Pathological characteristics include chronic inflammation, excessive collagen deposition in the connective tissues below the oral mucous epithelium and local inflammation in the lamina ...
mouse model Büsra Öztürk Akcora1, Gert Storm1,2, Jai Prakash1 & Ruchi Bansal1 Hepatic fibrosis, a progressive chronic disease mainly caused by hepatitis viral infections, alcohol abuse or metabolic syndrome leading to liver dysfunction and is the growing cause of mortality worldwide....
Finally, 1,231 young pwCF were included in the analyses. Sex, CFTR genotype, meconium ileus, CF-related diabetes (CFRD), and CF-related liver disease (CFLD) were analysed (see Supplementary Information for CFRD and CFLD definitions). We ranked the CF centres according to the number of p...
CCL20 serves as a chemoattractant molecule for immature dendritic cells, which have been shown to produce many of the inflammatory molecules that mediate liver fibrosis. These data also point to hepatic stellate cells as a key cell type that may respond to lipid loading of the liver. Keywords:...