Alcohol-related liver diseaseNon-alcoholic fatty liver diseaseFibrosisHistological stagingRegressionPathogenesisHistological fibrosis stage is one of the most important prognostic factors in compensated and decompensated alcohol-related liver disease (ALD). Morphological assessment of fibrosis is useful for ...
interventions to reduce mortality and morbidity from alcohol-related liver disease, spanning the entire spectrum of disease: primary prevention to reduce overall alcohol-related harm, secondary prevention to attenuate fibrosis progression and tertiary prevention using antibiotics for severe alcohol-associated ...
Alcohol is one of the main factors of liver damage. The evaluation of the degree of liver fibrosis is of great value for therapeutic decision making in patients with alcoholic liver disease(ALD). Staging of liver fibrosis is essential to define prognosis and management of the disease. Liver bio...
Alcohol Use Disorders (AUDs) cause 80% of hepatotoxic deaths, and approximately 50% of cirrhosis is alcoholrelated. The acceptable daily intake (ADI) for ethanol is 2.6 g/day, deduced from morbidity and mortality rates due to liver fibrosis. The relative risk of cirrhosis increases significantly...
An ELISA employing a monoclonal antibody targeting HSP47-C was developed and technically validated. The assay was evaluated in serum from a cross-sectional biopsy-controlled study of 281 patients with alcohol-related liver disease (ALD) and 50 gender, age and BMI matched healthy controls (HC). ...
Fibrosis, defined by the excess deposition of structural and matricellular proteins in the extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved antifibrotics have proven modest in efficacy, and the immune compartment remains, for the most part, an untapped therapeutic ...
Excessive ECM is deposited in the portal area of the liver to form collagen fibers, which destroys the normal structure and function of the liver and stimulates inflammatory signaling pathways [1]. Chronic liver disease, caused by virus, alcohol, fat, drug, and autoimmunity, will result in the...
Hepatitis B viral (HBV) infection is the major cause of liver fibrosis in China, whereas hepatitis C viral (HCV) infection and alcohol are the main causes in the United States, Europe and Japan [1–4]. Liver fibrosis may progress into liver cirrhosis and other complications coupled with ...
Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of hepatic steatosis not due to excess alcohol consumption. The prevalence of NAFLD is... BW Smith,LA Adams - 《Critical Reviews in Clinical Laboratory Sciences》 被引量: 139发表: 2011年 加载更多来源...
In the present study, the following individuals were excluded: (1) individuals (n = 19) with cirrhosis of any etiology or chronic liver disease due to excessive alcohol consumption (alcohol consumption > 30 g/day for men and > 20 g/day for women) or viral hepatitis based on...