Liver fibrosis represents a general wound-healing response to a variety of insults. Although mortality due to alcohol abuse has been constantly decreasing in the past 20 years in Southern Europe and North America, in several Eastern-European countries and Great Britain Alcoholic Liver Disease (ALD)...
Liver fibrosis is the formation of tissue scars in the liver due tochronic inflammationand injury. Over time, fibrosis can impair liver function and may lead to cirrhosis or evenliver cancer. Those at risk include individuals with chronic viral hepatitis, obesity, diabetes and excessive alcohol use...
When hepatocytes (functional liver cells) are injured due to a virus, alcohol, toxins, trauma or other factors, the immune system goes to work to repair the damage. During the fibrosis process, the injured hepatocytes cause substances to be released into the liver causing the buildup of the ...
Type 2 diabetes (T2D) in associated with higher prevalence and worse outcomes of nonalcoholic fatty liver disease (NAFLD). However, data regarding the prevalence of clinically relevant liver fibrosis (CRLF) in Indian individuals with T2D are scarce. We investigated the prevalence of, and factors ...
Alcohol Use Disorders (AUDs) cause 80% of hepatotoxic deaths, and approximately 50% of cirrhosis is alcoholrelated. The acceptable daily intake (ADI) for ethanol is 2.6 g/day, deduced from morbidity and mortality rates due to liver fibrosis. The relative risk of cirrhosis increases significantly...
Alcoholic liver disease. Fatty liver Fibrosis Hepatitis Cirrhosis of the liver. illustration. Any kind of alcohol can cause liver damage.,站酷海洛,一站式正版视觉内容平台,站酷旗下品牌.授权内容包含正版商业图片、艺术插画、矢量、视频、音乐素材、字体等,已
CLD has various etiologies including chronic alcohol consumption, infectious diseases, such as viral hepatitis, exposure to toxins and drugs, persistent autoimmune injury, or chronic conditions of altered metabolism. Whatever its etiology, the evolution of liver fibrosis is characterized (Bataller and ...
et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc. Natl Acad. Sci. USA 109, 9448–9453 (2012). Article CAS PubMed PubMed Central Google Scholar Yao, L. et al. Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in ...
“Acute binge alcohol modulates the levels of cannabinoid receptor expression in the lung. •Microbial challenge induces pulmonary inflammation in mice previously exposed to binge alcohol •Excessive alcohol paired with microbial challenge contributes to the release of proinflammatory cytokines in the lung...
Core Tip:Peroxisome proliferator activated receptor (PPAR) α and δ play a key role in lipid metabolism and intestinal barrier homeostasis, which are major contributors to alcohol-associated liver disease (ALD) pathogenesis. This study elucidates the preventive effect of elafibranor, a dual PPARα...