skinagingfibroblastsproliferationPCNAFibroblasts synthesize all components of the extracellular matrix of the dermis, including collagen, elastin, proteoglycans, and minor proteins. Consequently, the changes in the size and functional status of these cells may disrupt the formation of intercellular substance,...
Fibroblast differentiation in wound healing and fibrosis. The contraction of granulation tissue from skin wounds was first described in the 1960s. Later it was discovered that during tissue repair, fibroblasts und... IA Darby,TD Hewitson - 《International Review of Cytology》 被引量: 650发表: 200...
Use of cardiotonic steroids as Na/K-ATPase ligands for the treatment of the skin This process relates to a pharmaceutical composition of an Na-K- ATPase ligand which will stimulate Na/K-ATPase signaling in a pharmaceutically acceptable vehicle. In one embodiment, the composition may be used to...
Integrins, especially αv integrin (ITGAV), are thought to play central roles in tissue fibrosis and the pathogenesis of scleroderma. So far, skin phenotype of tissue-specific transgenic mice of ITGAV have not been investigated. To investigate the role of ITGAV in the skin fibrosis, we engineere...
Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes. Gibbs, "Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes," Wound Repair and Regeneration, vol. 15, no. ... SW Spiekstra,M Breetveld,T Rustemeyer...
Interestingly, we could not detect 13C5-proline-containing Col1a peptides in the skin (Fig. 1i), even though the total levels of collagen were similar to those in the tumours (Extended Data Fig. 1l, Supplementary Data 3, datasheets ‘LFQ intensity collagens tum-skin’ and ‘H/L ratio...
In the skin, fibroblasts have been shown to influence dermal regeneration by secreting specific ECM components (reviewed elsewhere73) and, in the case of hair production, fibroblasts are also essential for regulating the stem cell niche. Of note, scarless free skin regeneration is restricted to fet...
The results of this study indicate that normalization of epidermal differentiation can be achieved using a non-contractile dermal matrix populated with fibroblasts. 展开 关键词: Skin substitute DED Dermal fibroblasts Keratinocytes Growth factors Human ...
Correct assay of complex I activity in human skin fibroblasts by timely addition of rotenone. L,Elly,A,... - 《Clinical Chemistry》 被引量: 17发表: 2008年 Spectrophotometric Assay for Complex I of the Respiratory Chain in Tissue Samples and Cultured Fibroblasts Conclusions: This spectrophotometric...
Fibroblasts are known to interact with other cell types in the skin. scRNA-seq provides opportunities to identify communicating pairs of cells based on the expression of cell-surface receptors and their interacting ligands. The results showed that fibroblasts interacted with all cells we identified in...