Although fibroblasts can synthesize nidogen and deposit it in the dermal matrix, no basal lamina will form unless they are recombined with keratinocytes. This suggests that the epidermis plays a major regulatory role in the production and assembly of nidogen into the basal lamina.Fleischmajer...
The function of a tissue is actually a function of its cells. And the function of a cell is a function of its cell structures. Which cell structure best helps simple squamous epithelium to function properly? Cells that s...
Superoxide dismutase is an enzyme that can repair cells and reduce damage from superoxide (the most common free radical in the body). Its English abbreviation is SOD. Superoxide dismutase can be found in the dermis and epidermis of human skin and is key to the production of healthy fibroblasts...
Beneath the epidermis lies the dermis, a robust layer containing fibroblasts, the cells responsible for producing essential proteins such as collagen and elastin. These proteins provide structure and elasticity, contributing to the skin’s strength and flexibility. Deeper still is the hypodermis,...
Fibrillin-1 expression by keratinocytes and dermal fibroblasts in photoprotected and photoaged skin suggests that both cell types contribute actively to maintaining the integrity of the microfibrillar network that extends from the DEJ into the papillary dermis. The presence of fibrillin-1 mRNA even in...
Interestingly, it is also low abundant in the dermis of elderly, while it appears highly enriched in the epidermis [67]. Thus, it is tempting to speculate that EV mediated cross-talk between fibroblasts and keratinocytes contributes to low dermal levels versus high epidermal levels. Functionally,...
Cancer-associated fibroblasts (CAFs) play a key role in cancer progression and treatment outcome. This study dissects the intra-tumoral diversity of CAFs in basal cell carcinoma, squamous cell carcinoma, and melanoma using molecular and spatial single-ce
They were generated from fibroblasts in skin biopsies taken from, in the case of the HD family series, three siblings with juvenile Huntington’s disease, carrying HTT mutations with 56, 67 and 73 CAG repeats respectively, and their unaffected parent (20 CAG repeats) as a non-disease control...
expression of ACTA2 was absent in the epidermis and dermal fibroblasts, but expression was detected in SM cells of blood vessels and skin appendages, whereas ACTB and ACTG1 were expressed both in the epidermis and all the dermis including dermal fibroblasts (Figure 1a, upper row) of unwounded...
Here, we explore how heterogeneity in developmental lineage and maturity of the starting cell population contributes to direct reprogramming using the conversion of murine fibroblasts into neurons. Our hypothesis is that a single lineage of cells contributes to most reprogramming and that a rare elite ...