Binding proteins that specifically bind to β-Klotho or portions thereof, FGFR1c or portions thereof, or both FGFR1c and β-Klotho, and optionally other proteins as well are provided. Coding sequences, methods of treatment and pharmaceutical compositions are also provided....
Provides Link Proteins that Bind specifically to B (beta) - Klotho or portions thereof, fgfr1c or portions thereof, or both fgfr1c and B (beta) - Klotho, and optionally other Proteins. Also provided are Coding sequences, Methods of treatment and Pharmaceutical compositions.LI PENG...
PS-108-NGM, a novel activator of beta-Klotho/FGFR1c: A single dose significantly reduces steatosis (liver fat by MRI-PDFF), inflammation (ALT, AST) and fibrogenic activity (Pro-C3) in NAFLD subjects - ScienceDirectdoi:10.1016/S0618-8278(19)30120-3Alex DePaoli...
HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING BETA-KLOTHO AND AN FGFR1cThe present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling.LI Yang...
Provides Link Proteins that Bind specifically to beta Klotho or portions thereof, fgfr1c or portions thereof, or both fgfr1c and beta Klotho, and optionally other Proteins. Also provided are Coding sequences, Methods of treatment and Pharmaceutical compositions.Claim 1: Binding Protein that binds ...