本发明的应用有益效果是:本发明通过不同浓度的人重组FGF21蛋白处理脂肪细胞,采用定量反转录聚合酶链式反应(qRT-PCR)检测脂肪细胞内的UCP1基因表达水平,从而确定脂肪细胞内UCP1表达水平成为人重组FGF21蛋白活性检测的新指标,操作过程简单,对环境的要求低,有很好的实用价值。 附图说明 图1是本发明细胞转变为成熟脂肪细...
UCP1Adipose tissueCircadian clockNutritionMetabolismFibroblast growth factor 21 (FGF21) exhibits a circadian oscillation, and its induction is critical during fasting. When secreted by liver and skeletal muscle, FGF21 enhances thermogenic activity in brown adipose tissue (BAT) by utilizing uncoupling ...
摘要 目的:探究PPARγ-FGF21-UCP1信号通路在孕期运动改善子代棕色脂肪生成和能量代谢中的作用。方法:孕鼠随机分为孕期安静组(p-Ctrl)和孕期运动组(p-EX),每组各24只。运动组进行无负重游泳训练(60 mi...展开更多 Purpose:To investigate the role of PPARγ-FGF21-UCP1 signaling pathway during prenatal ...
Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite coreceptor βKlotho. ...
摘要：目的：探究PPARγ-FGF21-UCP1信号通路在孕期运动改善子代棕色脂肪生成和能量代谢中的作用。方法：孕鼠随机分为孕期安静组（p-Ctrl）和孕期运动组（p-EX），每组各24只。运动组进行无负重游泳训练（60 min/d，6 d/周，妊娠第1～18 d）。以胎鼠（胚胎期第19 d）和出生后21 d的子代小鼠为研究对象；...
In WT mice, this effect is solely due to increased EE, associated with a strong activation of UCP1 and with excess heat dissipated through the tail. This thermogenesis takes place in the interscapular region and can be attenuated by a β-adrenergic inhibitor propranolol. In KO mice, FGF21-...
研究表明,限制蛋白质或支链氨基酸的有益代谢作用主要是通过限制异亮氨酸介导的。 低异亮氨酸饮食可重新编程肝脏和脂肪代谢,增加肝脏胰岛素敏感性和生酮作用,激起增强棕色脂肪组织产热的FGF21-UCP1轴,增加能量消耗。 反之,膳食异亮氨酸摄入量增 +1 发布于 2024-10-08 09:26・IP 属地上海 赞同1 分享收藏 ...
The article reports that weight loss can be induced along with improvement in glucose homeostasis through fibroblast growth factor 21 (FGF-21), which is linked with increased expression of uncoupling protein 1 (UCP1), and browning of white adipose tissue (WAT).Geach...
The article reports that weight loss can be induced along with improvement in glucose homeostasis through fibroblast growth factor 21 (FGF-21), which is linked with increased expression of uncoupling protein 1 (UCP1), and browning of white adipose tissue (WAT)....
While energy expenditure did not display significant differences, UCP1 KO females significantly increased their food intake. Altogether, our results indicate that hyperphagia is likely counteracting the beneficial effects of FGF21 in female mice. This underlines the importance of sex-specific studies in ...