转化生长因子⁃β1(transformation growth factor⁃beta 1,TGF⁃β1)可转化细胞表型,并与细胞增殖密切相关,具有诱导生长的作用 [5] 。既往大多研究只用其一作为诱导剂,使BMSCs 向心肌细胞定向分化。而本研究应用了 FGF⁃2 与 TGF⁃β1 单独及两种药物联合诱导doi:10.3969/j.issn.1006⁃5725.2017.24.001...
Cleary MA, van Osch GJ, Brama PA, Hellingman CA, Narcisi R (2015) FGF, TGFbeta and Wnt crosstalk: embryonic to in vitro cartilage development from mesenchymal stem cells. J Tissue Eng Regen Med 9(4):332-342. doi:10.1002/term.1744...
Importantly, the effect of FGF signaling inhibition on TGFβactivity was specific. Knockdowns of epidermal growth factor receptor (EGFR), insulin-like growth factor-1 receptor (IGF1R), and platelet-derived growth factor receptor beta (PDGFRβ) had little effect on TGFβR1 protein expression or S...
上皮-间质转化 (EMT) EMT指的是上皮细胞获得间质特征的过程,与肿瘤的发生、转移、侵袭有关。FGF/FGFR信号可与TGF-β合作,在 EMT诱导和肿瘤生长中发挥作用[17]。另外,FGFR2 IIIb和FGFR2 IIIc亚型之间的转换诱导了EMT,这种转换可能...
Up-regulation of S100A8 by FGF-2/IL-1β, down-regulation by TGF-β, and its time-dependent expression in wound fibroblasts suggest a role in fibroblast differentiation at sites of inflammation and repair. 展开 关键词: FGF-2 fibroblasts interleukin-1β S100A8 gene TGF-β ...
TGF-beta regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. The epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair, and cancer progression in adult tissues. Here, we demonstra... T Shirakihara,K Horiguchi,K Miyazawa,... - ...
Studies have highlighted the significance of transforming growth factor beta (TGF-β) signaling in promoting OC progression through its interaction with CAFs [10, 11]. Activation of the c-Met/PI3K/Akt and GRP78 signaling pathways by CAFs-derived hepatocyte growth factor (HGF) promotes cell ...
【企业资讯】近岸类器官课堂：类器官培养关键细胞因子之FGF家族 FGF家族 ✦ ✦ ✦ FGF 也称为成纤维细胞生长因子（Fibroblast growth factors，FGFs），是一个包括大约 20 多种肝素结合蛋白的蛋白家族，它们在与大脑、皮肤和肺等组织发育和修复相关的许多细胞过程中发挥着关键作用。FGF家族至少有20个成员，命名为...
accepted 19 April 2005Available online 15 June 2005AbstractDisturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgfb) signaling lead to a variety of human skeletal disorders.To reveal the possible function and interaction of these signaling systems we have started to analyze ...
TGF-beta s and TGF-beta type II receptor in human epidermis: differential expression in acute and chronic skin wounds. Exogenously applied transforming growth factor-beta (TGF-β) isoforms enhance wound healing processes in animal models; 1 however, little is known about t... P Schmid,D Cox,...