Full size image Consistent with these findings, FGF19 treatment led to transient increases in phosphorylated (p)-Tyr-FXR levels that peaked at 10 min and returned to basal levels after 30–60 min (Fig.1b) while treatment of hepatocytes with insulin or a synthetic FXR agonist, GW4064, ...
Studies in humans and mice also reveal that FGFR1 play crucial role in bone formation. A gain-of-function mutation in FGFR1 (P252R) leads to Pfeiffer syndrome (PS), one type of craniosynostoses, characterized by premature fusion of one or several calvarial sutures.27Several activating mutation...
Subarachnoid hemorrhage (SAH) represents a form of cerebrovascular event characterized by a notable mortality and morbidity rate. Fibroblast growth factor 21 (FGF21), a versatile hormone predominantly synthesized by the hepatic tissue, has emerged as a p
Male germline differentiation depends on development of an appropriate testicular environment. In XY mice,Sry(sex determining region Y) andSox9(SRY box 9) drive pre-supporting cell commitment to Sertoli cell development at E11.5 [4,5]. Sertoli cells form testis cords that enclose germ cells, a ...
Download: Download full-size image Figure 2. The secretion from ferroptotic fibroblasts by BACH1 re-expression suppresses senescence in other cells (A–D, G, and H) The control or Tet-ON BACH1 genes were introduced into Bach1−/− iMEFs using retrovirus vectors, and Hepa1 cells were ...
In hepatocytes and circulation, FGF23 was present only strictly linked to Fetuin-A, while Fetuin-A was found also in unbounded form. No link was observed in the kidney. FGF23 up to 600 pg/ml stimulates, while, at higher concentrations, reduces Fetuin-A expression. Notably, overall the ...
Thus, the adipose-derived FGF21-CCL11 axis triggers cold-induced beiging and thermogenesis by coupling sympathetic nervous system to activation of type 2 immunity in scWAT. Graphical Abstract Download: Download high-res image (242KB) Download: Download full-size image...
Life did itself proud, with an astonishing 17 full pages of color photos of the 4,500-mile border of the Socialist Bloc, at every point of which soldiers stand ready to kill those who flee. READ REST OF ARTICLE Donate Journalism v. Conservatism by Joe Sobran January 12, 2018 The...
integumentscalelessIn a previous report, we showed that fibroblast growth factor-2 (FGF-2) is a signal produced by epidermal placode cells during feather development and that this growth factor can induce feathers in scaleless mutant skins that fail to form feathers due to a defective epidermis ...
Full size image Treatment of murine brown preadipocytes with different concentrations of recombinant FGFs for 24 h verified the screen results and demonstrated that FGF6 and FGF9 could robustly induceUcp1expression in brown preadipocytes in a dose-dependent manner (Fig.1cand Supplementary Fig.1d...