By high-throughput screening of small molecule libraries, it was independently reported that fer-1 [1] and liproxstatin-1 (lip-1) [22] act as potent inhibitors of ferroptosis, [22,23]. Unexpectedly, α-tocophero
Synthetic RTA Ferrostatins Fer-1 [2] UAMC-3203 [49] SRS11-92, SRS9-11, SRS16-86, UAMC-2418, CFI-4061, CFI-4082 [46,47] Liproxstatins Lip-1 [54] Lip-2 [55] Tricyclic RTAs Phenothiazine [56] 2-{1-[4-(4-methylpiperazin-1-yl)phenyl]ethyl}-10H-phenothiazine, 4-{4-[1-(10H...
ferroptosis is regulated by a series of specific genes, including GPX4, lipoxygenase (LOX), Acyl—CoA synthetase long- chain family member 4 (ACSL4), P53 and solute carrier family 7 member 11 (SLC7A11), etc., and can be specifically inhibited by ferrostatin-1 and liproxstatin [9, 10]....
ferroptosis is regulated by a series of specific genes, including GPX4, lipoxygenase (LOX), Acyl—CoA synthetase long- chain family member 4 (ACSL4), P53 and solute carrier family 7 member 11 (SLC7A11), etc., and can be specifically inhibited by ferrostatin-1 and liproxstatin [9, 10]....
On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death ACS Cent. Sci., 3 (2017), pp. 232-243, 10.1021/acscentsci.7b00028 View in ScopusGoogle Scholar [12] R. Shah, M.S. Shchepinov, D.A. Pratt Resolving ...