Bioinformatics analysis revealed that GPX4 was involved in the fibrosis formation of AAA, and there was an interaction between SLC7A11 and GPX4. In?vitro assays showed that Fer‐1 alleviated Ang II‐induced ferroptosis of VSMCs and retard the consequent AAA formation. The mechanism was associated...
申请公布日期: 2021-05-11 代理机构: 苏州市中南伟业知识产权代理事务所(普通合伙) 代理人: 曹成俊 地址: 215000 江苏省苏州市三香路1055号 摘要: 本发明公开了一种Ferrostatin‑1在治疗骨质疏松疾病中的用途,属于医药技术领域。本发明用Ferrostatin‑1干预Ⅰ型骨质疏松动物模型,发现其具有一定的抗骨质疏松作用。
The cell viability of BEAS-2B was down-regulated by LPS treatment, together with the ferroptosis markers SLC7A11 and GPX4, while the levels of MDA, 4-HNE and total iron were increased by LPS treatment in a dose-dependent manner, which could be rescued by Fer-1. The results of the in ...
它还选择性地诱导表达 SV40 小 T 癌蛋白和致癌 Ras 的细胞死亡(IC50s = 1.25- 发布于 2023-04-06 11:18・IP 属地天津 写下你的评论... 登录知乎,您可以享受以下权益: 更懂你的优质内容 更专业的大咖答主 更深度的互动交流 更高效的创作环境 立即登录/注册...