Ferroptosis Suppressor Protein 1 (FSP1)BACKGROUND. There are currently no proven therapies for metastatic or unresectable Chromophobe renal cell carcinoma (ChRCC). Ferroptosis is an iron-dependent form of cell death characterized by the peroxidation of membrane polyunsaturated fatty acids, leading to ...
is involved in oxidoreductase function and can induce programmed cell death [45]. Recently, AIFM2 was recognised as an anti-iron porphyrin gene and was later renamed ferrocyte apoptosis suppressor protein 1 (FSP1). FSP1 inhibits iron through ubiquitin ketone (CoQ10...
68], implying that there are other ferroptosis defence mechanisms. Ferroptosis suppressor 1 (FSP1) inhibits ferroptosis independently of GPX4 [68,69]. By reducing CoenzymeQ10 (CoQ), FSP1 prevents lipid peroxidation and suppresses ferroptosis [68,69]. Similarly, in the mitochondrial inner ...
1, ferroptosis suppressor protein 1; GCH1, GTP cyclohydrolase 1; GPX4, glutathione peroxidase 4; GSH, glutathione; GSSG, glutathione disulfide; HO-1, heme oxygenase 1; Keap1, Kelch-like ECH-associated protein 1; LOX, lipoxygenase; LPCAT, lysophosphatidylcholine acyltransferase; MUFA, monounsaturated...
Ferroptosis suppressor protein 1 (FSP1, also known as AIMF2, AMID or PRG3) is a recently identified glutathione-independent ferroptosis suppressor1–3, but its underlying structural mechanism remains unknown. Here we report the crystal structures of Gall
We found that the flavoprotein apoptosis-inducing factor mitochondria-associated 2 (AIFM2) is a previously unrecognized anti-ferroptotic gene. AIFM2, which we renamed ferroptosis suppressor protein 1 (FSP1) and which was initially described as a pro-apoptotic gene11, confers protection against ...
by ferroptosis suppressor protein 1 (FSP1) [16]. In the inner mitochondrial membrane, CoQH2 can be reduced from CoQ by dihydroorotate dehydrogenase (DHODH) to scavenge lipid peroxides and inhibit ferroptosis [17]. (3) Tetrahydrobiopterin (BH4) biosynthesis is catalyzed by a series of enzymes, ...
Recently, ferroptosis suppressor protein 1 (FSP1), formerly designated apoptosis-inducing factor mitochondria associated 2 (AIFM2), was identified as another effective ferroptosis-resistance factor.39,40After myristoylation, FSP1 is recruited to the plasma membrane where it functions as an oxidoreductase...
critical antioxidant enzymes, including glutathione (GSH)/glutathione peroxidase 4 (GPX4), coenzyme Q10 (CoQ10)/ferroptosis suppressor protein 1 (FSP1),22nuclear factor erythroid 2-like 2 (Nrf2), dihydroorotate dehydrogenase (DHODH)33,34and genes involved in lipid metabolism, such as acyl-CoA ...
demonstrated that NADPH was used to regenerate CoQH2 by ferroptosis suppressor protein 1 (FSP1), which restrains ferroptosis [16]. Consistent with these findings, other studies confirmed that NADPH was used to generate NO, which suppressed ferroptosis [48, 49]. Otherwise, NADPH contributes to ...