particularly in cancer biology. Among its pleiotropic functions, our findings highlight CDK1’s crucial role in regulating FOXM1 in human primary keratinocytes from both healthy donors and JEB patients. We prop
Rh3, Rh5, and Rh6 are further restricted to specific PR subtypes by Sens, Pros, Ss (via Dve), and the Wts/Melt loop. We also show that Dve is expressed in yR7s at levels that are sufficient to repress Rh3 throughout most of the retina but low enough to allow for IroC-mediated ...
Our examples so far included sharp steps in X, but fold response is also seen for gradually changing signal profiles (Figure S1). For illustration, Figure S2 shows how all other network motifs, including positive and negative autoregulation, coherent FFLs, and single-input modules, respond to ...
15 Our observation that BATF3 induces the expression of S1PR1 identifies a feedforward loop, which leads to constitutive S1P signalling, activation of the PI3-K/Akt pathway and sustained BATF3 transcriptional activity (Figure 8). The major source of the S1P necessary to sustain this loop is ...
Synthetic biology has the potential to bring forth advanced genetic devices for applications in healthcare and biotechnology. However, accurately predicting the behavior of engineered genetic devices remains difficult due to lack of modularity, wherein a
Black arrows, cause and effect; red arrows, components of feedforward loop; dotted, blunt-headed line, masked stimulation. An interesting finding here is that GPER/GPR30 mediates the E2 effect of up-regulating CaM, which in turn is important for the receptor's functions. This role of GPER/...
The original SOM algorithm is modified in order to obtain multiple local linear models, which would allow its incorporation into a closed-loop glucose controller. Besides the glucose signal, information on the energy expenditure (EE) during daily physical activities is also exploited. In particular,...
A graphical display of the two-layer feedforward networks that are used as examples are given in Figs. 4 and 5 in the "Methods" section below. Subsequently, we want to shed light on our motivation to provide examples for the use of these networks. The reason why we want to provide ...
The feedforward loop described here could be important for the pathogenesis of HL as it has been shown that the knockdown of BATF3 significantly reduces the survival of HL cell lines44 and that BATF3 can induce B-cell lymphomas in a murine model (Weiser et al, personal communication). Our...