Our examples so far included sharp steps in X, but fold response is also seen for gradually changing signal profiles (Figure S1). For illustration, Figure S2 shows how all other network motifs, including positive and negative autoregulation, coherent FFLs, and single-input modules, respond to ...
Synthetic biology has the potential to bring forth advanced genetic devices for applications in healthcare and biotechnology. However, accurately predicting the behavior of engineered genetic devices remains difficult due to lack of modularity, wherein a
15 Our observation that BATF3 induces the expression of S1PR1 identifies a feedforward loop, which leads to constitutive S1P signalling, activation of the PI3-K/Akt pathway and sustained BATF3 transcriptional activity (Figure 8). The major source of the S1P necessary to sustain this loop is ...
(2006). Transient resetting: A novel mechanism for synchrony and its biological examples. PLoS Computational Biology, 2, e103. Article Google Scholar Lindner, B., & Schimansky-Geier, L. (2002). Maximizing spike train coherence or incoherence in the leaky integrate-and-fire model. Physical ...
45. Such studies provide valuable insights into the intrinsic self-organizing behaviour of engineered neural networks. In this study, we build upon these insights by reverse engineering an anatomically relevant feedforward microcircuit recapitulating key connections in the cortical-hippocampal loop. As ...
The feedforward loop described here could be important for the pathogenesis of HL as it has been shown that the knockdown of BATF3 significantly reduces the survival of HL cell lines44 and that BATF3 can induce B-cell lymphomas in a murine model (Weiser et al, personal communication). Our...