To avoid the complexity of path enumeration, we define generalized feed-forward loops as pairs of source and target nodes that have two or more internally disjoint connecting paths. Based on this definition, we formally derive an approach for the detection of this generalized motif. Our ...
With a series of simplified models, we studied the underlying mechanism and found that theclock consists of type-2 incoherent feed-forward loops (IFFLs), one of them creating a pulse-like expression in. The double-negative feedback loop betweenandgenerates a bistable, hysteretic behavior in the...
Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation The eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of executor proteins (EPs) involved in cell growth and divis... A Csikã¡Sz-Nagy,O Kapuy,A Tã³Th,... - ...
Oosawa, C., Takemoto, K., Savageau, M.A.: Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. In: Proceedings of the 13th International Symposium on Artificial Life and Robotics, pp. 885-890, http://arxiv.org/abs/0711.2730v2 [arXiv:0711.2730...
1.Jiang Y, Hao N. Memorizing environmental signals through feedback and feedforward loops. Curr Opin Cell Biol. 2021 Apr;69:96-102. doi: 10.1016/j.ceb.2020.11.008. Epub 2021 Feb 4. PMID: 33549848; PMCID: PMC8058236. 咨询更多国自然...
While these patterns of gene expression are consistent with a dependent sequence of developmental stages (Loomis et al., 1976), further dissection of the causal connections may indicate more complex arrangements such as cooperative, bi-furcating, or feed-forward loops. Microarrays carrying 6450 cDNA...
Systematic identification and analysis of dysregulated miRNA and transcription factor feed-forward loops in hypertrophic cardiomyopathy H Shi,J Li,Q Song,... - J Cell Mol Med 被引量: 0发表: 2019年 MicroRNAs as Regulators of Signal Transduction in Urological Tumors tumors and are dysregulated in ...
the existence of feedback loops controlling both strength and spatial distribution of WNT and BMP signals in gastric glands. The deficiency of BMP signaling promotes gland hyperplasia Smad4 is one of the central mediators through which transforming growth factor-β/BMP signaling regulates gene ...
10 Genetic disorders and complex diseases have been found to be associated with perturbations of the intertwined regulatory network between TFs and miRNAs.11 Moreover, TFs and miRNAs frequently form feed-forward loops to regulate transcription of functionally critical genes.12 Over the last decade, a...
2) auxiliary feed-forward loops 辅助前馈通路 3) feedforward 前馈 1. Application offeedforwardand feedback control strategy to rolling line of control cooling in Baosteel Wiring Mill; 前馈和反馈相结合的控制策略在宝钢线材厂控冷轧线上的应用实践 ...