3.3.4 Variable and Dataset Descriptor Length 变量和数据集描述符长度The length of variable names, descriptive labels, and dataset labels should not exceed the maximum permissible number of characters described in Table 1变量名称、描述性标签和数据集标签的长度不应超过表 1 中描述的最大允许字符数 3.3....
Mining FDA drug labels using an unsupervised learning technique-topic modeling. BMC bioinformatics. 2011; 12(10):S11. 30. Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P. A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol. 2010;6(1):343. 31. Campillos M,...
Data on drug indication’s background-, treatment-, disease-, and trial-related factors were collected from FDA labels, clinicaltrials.gov, and the Global Burden of Disease study. The association between patient accrual and collected variables was assessed in Poisson regression models reporting ...
Because a drug is designated an “Orphan” if it is intended to treat a “rare condition,” the condition itself always has been integral to Orphan Drug Exclusivity. Indeed, the condition for which the product is intended to treat dictates the prevalence calculation by which FDA determines eligi...
Finally, we manually curated all drug-cardiovascular (CV) pairs that appeared in both data sources and investigated whether our approach can detect many true signals that have not been included in FDA drug labels. We extracted a total of 2,787,797 drug-SE pairs from FAERS with a low ...
DIQTA categorizes drugs based on a specific form of cardiotoxicity, drug-induced QT interval prolongation, using FDA labels as its basis. This dataset encompasses 528 drugs distributed across categories such as Most-DIQT-Concern (110 drugs), Moderate-DIQT-Concern (56 drugs), Ambiguous-DICT-Conce...
toward female sex andAPOE4 status may also explain why hormone replacement therapy is more effective inAPOE4carriers. The pathologic nature of FDAMic suggests that selective modulations of these cells may help to regain brain neuroimmune homeostasis, serving as a new target for future drug ...
(4) mRNA-seq of drug-treated xenograft tumors, and (5) in vitro analysis for inhibitory activity using three different approaches: activity assays with recombinant enzymes; kinome-wide profiling using the commercial KINOMEscan platform from DiscoverX (Fabian et al., 2005); and kinase enrichment ...
Whilst this dataset already has some scores for toxicity, quality, humour etc., we may want to get a better understanding of what types of conversations are represented in this dataset. BERTopic offers one way of getting a better understanding of the topics in this dataset. In this case, ...