The inbred, albino Osborne-Mendel (OM) rat is a model of diet-induced obesity, becoming obese on a high-fat (36% fat) diet (Schemmel et al., 1970). A high incidence of spontaneous tumors has been noted in the this rat, including thyroid carcinoma (33%), adrenal cortical tumors (94...
The uniqueness of albumin as a carrier in nanodrug delivery. Mol. Pharm. 18, 1862–1894 (2021). Article CAS Google Scholar Jain, R. K. & Stylianopoulos, T. Delivering nanomedicine to solid tumors. Nat. Rev. Clin. Oncol. 7, 653–664 (2010). Article CAS Google Scholar Bertrand, ...
My first concern would be that these could be some type of mammary tumors. However, it's a little bit odd to have two pop up at the same time. Mammary tumors can be hard to diagnose on a cat. They don't tend to shed cells easily so we can't do the normal type of test where...
characterized and RNA probes have been used in nuclease protectionassays to show that some classes of human tumors exhibit increased levels of desaturase mRNA. A structural gene for Δ9 desaturase of yeast (OLE-1) also has been isolated and characterized; rat liver Δ9 desaturase can effectivel...
There has been and continues to be a tremendous amount of research with the goal of finding a cure for brain tumors, yet there are only 3FDA approveddrugs for this indication, BCNU in the form of Gliadel® wafers, temozolomide (Temodar®), since 2005 and most recently, 2009 bevacizumab...
In cancer, VEGF-B expression (or over-expression) may control the 10 energy status of the tumor cells by providing high energy fuel as FFA, and thus affecting the growth rate, as well as other physiological parameters of tumors (both tumor cells as well as stroma). Furthermore, VEGF-B ...
in the blood, liver, bile, and small intestine, while the largest proportion of free bile acids are found in the colon and feces. Taurine conjugates are the predominant ones in the bile acid pool of mice, rats, and dogs, whereas in humans, hamsters, and rabbits, the bile acid pool is...
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(FRE), as well as its relationship with body condition and the chronic enteropathy activity index. Changes in the long-chain fatty acid of plasma, and short-chain, branched and odd-chain fatty acids of faeces were detected in sick dogs, and high correlations were observed between some of ...
This preliminary study suggests a specific protective effect of some long-chain ω3 PUFA, EPA and DHA when carried by Non-HDL lipoproteins, only in patients with hormone-receptor-negative tumors. These results have been observed in a clinical study and confirmed by an in vitro approach. Experime...