Peptides and proteins are widely used to treat a range of medical conditions; however, they often have to be injected and their effects are short-lived. These shortcomings of the native structure can be addressed by molecular engineering, but this is a c
The inbred, albino Osborne-Mendel (OM) rat is a model of diet-induced obesity, becoming obese on a high-fat (36% fat) diet (Schemmel et al., 1970). A high incidence of spontaneous tumors has been noted in the this rat, including thyroid carcinoma (33%), adrenal cortical tumors (94...
"Dietary consumption of omega-3 fatty acids can lead to the formation of these substances in the body and may have some beneficial effects," said study leader Aditi Das, a professor of comparative biosciences and an affiliate of biochemistry at UI. "If you have cancer, you want something con...
When it comes to the pathophysiological setting of obesity, the effect of FXR is less clear. Conflicting findings have unveiled the complexity of influence of FXR or SHP on lipid and glucose homeostasis. FXR activation improves diet-induced hepatic steatosis, hyperglycemia, and hyperlipidemia in diabe...
8 In this regard, SIRT1 was originally considered to be a potential tumor promoter by its inhibitory effect on p53,23 raising the concern that overexpressing SIRT1 long-term in humans could lead to the development of hepatic tumors. However, studies in transgenic animal models in which SIRT1 ...
(Kidney) Cancer; Renal Pelvis and Ureter, Transitional Cell Cancer; Respiratory Tract Carcinoma Involving the NUT Gene on Chromosome 15; Retinoblastoma; Rhabdomyosarcoma; Salivary Gland Cancer; Sarcoma, Ewing Family of Tumors; Sarcoma, Kaposi; Sarcoma, Soft Tissue; Sarcoma, Uterine; Sezary Syndrome; ...
"Particular cancers that might be most interesting to study would be solid tumors or carcinomas, which tend to spread and cause pain within the skeleton. Some of the most common tumors that behave this way are breast, prostate, and lung carcinomas, and we can certainly explore these tumors ...
This is a tough question to answer without being able to see and touch these lumps, but I can give you a few of my thoughts as to what might be going on. My first concern would be that these could be some type of mammary tumors. However, it's a little bit odd to have two pop...
characterized and RNA probes have been used in nuclease protectionassays to show that some classes of human tumors exhibit increased levels of desaturase mRNA. A structural gene for Δ9 desaturase of yeast (OLE-1) also has been isolated and characterized; rat liver Δ9 desaturase can effectivel...