The yellow color seen upon gross inspection of these lesions is associated with lipid deposition (cholesterol esters and free cholesterol) within these intimal cells as well as extracellularly. Fatty streaks are
FATP1 is highly expressed in the skeletal muscle, heart, and adipose tissue, whereas FATP2 is expressed primarily in the liver and kidney. In mouse, FATP3 is highly expressed in the adrenal gland, testis, ovary, and lung. FATP4 is the primary fatty acid transporter in the intestine. It...
i.e., whether there is fat alone or NASH is present. Isolated fatty liver does not progress to important liver disease. NASH, on the other hand, can progress through the formation of scar (fibrous tissue) tocirrhosis. The complications of cirrhosis, primarily...
Mfsd2a is the transporter for docosahexaenoic acid (DHA), an omega-3 fatty acid, across the blood brain barrier (BBB). Defects in Mfsd2a are linked to ailments from behavioral and motor dysfunctions to microcephaly. Mfsd2a transports long-chain unsaturat
Lipid accumulation is probably a result of over- flow after the adipose tissue expansion is exceeded. Indeed, hepatocytes undergo cellular stress due to lipotoxicity when the excess accumulation of free fatty acids (FAs) cannot be disarmed through the lipid storage mechanism or FA oxida- tion [8...
During metabolic stress, adipose tissue is more likely to release free fatty acids (FFA) in the serum resulting in an increase of FFA levels not only in blood, but also in follicular fluid (FF). In humans, high concentrations of palmitic acid and stearic acid reduced granulosa cell survival...
Obesity is defined as excessive accumulation or improper distribution of body fat (BF).1 Other concomitant illnesses include type 2 diabetes mellitus (T2DM), hepatic steatosis, cardiovascular disea...
Childhood obesity is a risk factor for numerous health conditions. A critical factor in the etiology of obesity appears to be the gut microbiota, which is the microbial community that resides in the human gut. The ratio of the phyla Firmicutes and Bacter
Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is not without consequences. In fact, hepatic steatosis contributes to the progression toward liver fibrosi
As stated above, it is unclear whether the NAGs are produced in CNS or whether other peripheral tissues are also involved in production of these signaling lipids. The wide distribution of the NAGs throughout the body (Bradshaw et al., 2009b), including NAGly, likely implies its involvement ...