Fisher’s equation as outlined above describes monolayer growth. However, tissue engineering strategies commonly rely on seeding appropriate cell populations onto complex three-dimensional porous biomimetic scaffolds in order to provide geometric support for tissue development [1,72]. In this situation, wh...
One of the best known and most commonly used synthetic biodegradable polymers in tissue engineering are the poly(lactic-co-glycolic) acid copolymers, which have been used in the form of biodegradable sutures for several decades. In 1988, Robert S. Langer (Massachusetts Institute of Technology) ...
It is worth mentioning that the commonly used AAVS1 locus is located within a high gene density TAD. In our cell line-based validation system, GFP cassette integration in AAVS1 significantly altered the expression of two nearby genes. Thus, there is an urgent need to identify more and better...
As per the ESMO guidelines [30], it is recommended that patients with intermediate/high grade tumours, which most commonly relapse within 2–3 years, should be followed every 3–4 months in the first 2–3 years, then twice a year up to the fifth year, and once a year thereafter for a...
SARS-CoV-2 inhibits lipolysis in subcutaneous fat cells The proteins altered in Sub AD and Vis AD cells in response to infection with the CoV-2(B) or CoV-2(P.1) lineages were commonly associated with the terms “Fatty acid metabolism” (Fig.4b) and “Metabolic pathways” (Supplementary ...
such as acupuncture, Chinese herbal formulas, and Chinese medicinal herbs. Moreover, pharmacological agents, functional foods, food ingredients, and the gut microbiota are also commonly associated with regulating and activating UCP1. The identification and analysis of UCP1 stimuli can greatly facilitate...
(5) Sustainability and environmental friendliness: Plants are commonly renewable resources, and their extraction process is relatively simple and sustainable. Several reviews have summarized the advantages of PDNVs as drug delivery tools [28, 105], we focus on the effects of PDNVs as drug delivery...
(DPP4)—this complex translocates into the nucleus where DPP4 can act as a transcription cofactor. However, inTP53mutants where p53 is reduced or absent, DPP4 forms a complex with NOX1 to promote lipid peroxidation.TP53is one of the most commonly mutated genes in CRC, and at least one ...
Decorin, biglycan, and lumican were commonly present in the top ten most abundant matrisome proteins of all batches of SEM or IEM samples (Fig. 2c–e, h), which are known to play important roles in collagen fibril formation69, cell proliferation70, maturation71, and epithelium homeostasis72...
[3]. Some of the endocrine and paracrine effects of the adipose tissue are mediated through the secretion of adipose-derived proteins or cytokines commonly referred to as adipokines. For example, leptin, the cytokine-like 16 kDa adipose-secreted protein discovered by positional cloning of theob/...