In caterpillar oral secretions, fatty acid amino acid conjugates (FACs) elicit plant defense responses during herbivory. The levels of these FAC elicitors within the caterpillar appear to be controlled by two enzymes, one in the gut tissue membranes that synthesizes FACs and the other in the gut...
zea. This variation was due to cleavage of the amide bond of the fatty acid-amino acid conjugates by an enzyme, or enzymes, ... Mori,Alborn,HT,... - 《Journal of Insect Physiology》 被引量: 221发表: 2001年 Phytohormone Conjugates: Nature and Function Reversible hormone conjugations in ...
The present invention relates to the use of N-fatty acid-amino acid conjugates to treat, prevent, or manage tissue inflammation, leukocyte adhesion, or pain. The invention includes pharmaceutical compositions comprising N-fatty acid-amino acid conjugates and methods of administering N-fatty acid-amino...
Aminoacylase 1 (ACY 1) is a cytosolic, homodimeric, zinc-binding enzyme that is also expressed primarily in kidney, liver and intestine15,16of mammals to catalyze the hydrolysis of N-acyl-L-amino acids to L-amino acids and acyl group for the catabolism and salvage of acylated amino acids17...
Various protraction mechanisms are enabled by the specific characteristics and positions of the attached fatty acid. Furthermore, the technology can ensure a long half-life following oral administration of peptide drugs, can alter the distribution of peptides and may hold potential for tissue targeting...
6.4.2. Amino acid-containing FAHFAs Several amino acid-containing acyloxyacyl lipids have been reported. Structurally (Fig. 9), they are composed of a 3-FAHFA bound to the amine group of an amino acid(lysine [286], glycine [287], ornithine [288,289], di- and tri-methylated ornithine ...
the carboxyl terminal, ε-amino terminal group of lysine residues, SH groups of cysteine, etc. Fatty acid chain lengths greater than two (2) carbon atoms were found to yield enhanced solubility of the corresponding FA-SP-C conjugates and improved surfactant activity of the resultant FA-SP-C/...
The degree of denaturation depends, among other factors, on pH as well as the acid concentration. The rate of denaturation follows first-order kinetics in respect to the protein, but the order in respect to the fatty acid is much higher. The energy of activation in the presence of acetic ...
An enzyme (M(r) 240,000) with high fatty acid alpha-oxidation activity has been purified from the fruit of cucumber (Cucumis sativus). The specific alpha-oxidation activity in the purified fraction was 370 nmol/min per mg protein determined as liberation of 14CO2 from [1-14C]palmitic acid...
This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids