In caterpillar oral secretions, fatty acid amino acid conjugates (FACs) elicit plant defense responses during herbivory. The levels of these FAC elicitors within the caterpillar appear to be controlled by two enzymes, one in the gut tissue membranes that synthesizes FACs and the other in the gut...
Fatty acidamino acid conjugates (FACs), a class of insect elicitors, resemble compounds synthesized by microbes in nature. Recent evidence suggests that the recognition of insect elicitors by an ancestral microbe-associated defense system may be the origin of tritrophic interactions mediated by FACs. ...
The present invention relates to the use of N-fatty acid-amino acid conjugates to treat, prevent, or manage tissue inflammation, leukocyte adhesion, or pain. The invention includes pharmaceutical compositions comprising N-fatty acid-amino acid conjugates and methods of administering N-fatty acid-amino...
Aminoacylase 1 (ACY 1) is a cytosolic, homodimeric, zinc-binding enzyme that is also expressed primarily in kidney, liver and intestine15,16of mammals to catalyze the hydrolysis of N-acyl-L-amino acids to L-amino acids and acyl group for the catabolism and salvage of acylated amino acids17...
et al. Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01334-x (2022). Article Google Scholar Prakash, T. P. et al. Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle. Nucleic Acids...
Fig. 9. Examples of Fatty acid esters of hydroxy fatty acids (FAHFAs) and derivatives. See text for details. They are essentially found in the outer membranes of Gram-negative bacteria and also in some Gram-positive bacteria. In 2010, Geiger published a review dedicated to these amino-acid...
prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the central nervous system, the prodrug is hydrolyzed into the fatty acid carrier and the drug to release the ...
This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids
An enzyme (M(r) 240,000) with high fatty acid alpha-oxidation activity has been purified from the fruit of cucumber (Cucumis sativus). The specific alpha-oxidation activity in the purified fraction was 370 nmol/min per mg protein determined as liberation of 14CO2 from [1-14C]palmitic acid...
SYNTHETIC APELIN FATTY ACID CONJUGATES WITH IMPROV 专利名称：SYNTHETIC APELIN FATTY ACID CONJUGATES WITH IMPROVED HALF-LIFE 发明人：ZECRI, Frederic,KANTER, Aaron,USERA,Aimee Richardson 申请号：IB2016/050206 申请日：20160115 公开号：WO2016/116842A1 公开日：20160728 专利内容由知识产权出版社提供 专利附...