2 Pathway of Fatty Acid Synthesis In all systems studied, Escherichia coli, yeast, pigeon liver, rat liver, and rat mammary gland, the basic steps of fatty acid synthesis from acetyl-CoA are the same (Vagelos, 1964). The first step is the formation of malonyl-CoA by the addition of an...
While accumulating studies are focused on the roles of glucose and amino acid metabolism in facilitating pluripotency, little is known regarding the role of lipid metabolism in regulation of stem cell activities. Here, we show that fatty acid (FA) synthesis activation is critical for stem cell ...
1 are the major products offatty acid synthesisin plastids.Enzymesinvolved in the synthesis, some sevenenzymes, catalyze individual steps and occur as a complex, referred to asfatty acid synthase, in the stroma of theplastid. This mode of fatty acid synthesis differs from that in animals and ...
Simplified schematic of de novo fatty acid synthesis.Kristina KirschnerShamith A. SamarajiwaJonathan M. CairnsSuraj MenonPedro A. PérezManceraKosuke TomimatsuCamino BermejoRodríguezYoko ItoTamir ChandraMasako Narita
The rate-limiting reaction for de novo fatty acid synthesis is catalyzed by acetyl-CoA carboxylase. As expected, its inhibiting phosphorylation decreased prior to cytokinesis initiation. Importantly, the inhibition of fatty acid synthesis arrested the cells at G2/M despite the presence of abundant ...
Fatty acid synthesis stops when a certain chain length is reached, and the acyl-ACP is used for membrane synthesis. As both reduction steps require two reduction equivalents, derived from nicotinamide adenine dinucleotide (NADPH), the following equation for the elongation of a fatty acid by a ...
Cancer cells need to adapt their metabolic state to different microenvironments, particularly during metastatic spread, when they are exposed to the circulatory system as well as the distant organ. Two studies now show that upregulation of fatty acid synthesis is required for the formation of breast...
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty acid synthesis in adipocytes induces necroptos
Summary of citrate export from the mitochondrial matrix and subsequent cytosolic fatty acid synthesis "Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular process that converts nutrients into metabolic intermediates for membrane biosynthesis... FA synthesis has ...
A recent study has reported that SIK2 is required for adipocyte-induced ovarian cancer (OC) survival through facilitating fatty acid oxidation. However, whether SIK2 also plays a role in the lipid synthesis in OC cells remains elusive. Here, we showed that SIK2 significantly promoted the lipid...