Fatty Acid Oxidation In subject area: Medicine and Dentistry Mitochondrial β-oxidation is the pathway by which fatty acids are fully oxidized to carbon dioxide and water, ultimately yielding more energy per mole and per gram of fatty acid than is released from complete oxidation of carbohydrate. ...
In rodents, n-3 polyunsaturated fatty acids (PUFAs) enhance hepatic fatty acid oxidation and inhibit fatty acid synthesis and very low-density lipoprotein secretion, in part, by regulating key transcription factors, including peroxisome proliferator activated receptor-? (PPAR-?), sterol regulatory ...
Fasting hormones such as glucagon regulate fatty acid oxidation in the liver through PPARα (10, 11). Glucagon stimulates PPARα activity and targets fatty acid oxidation gene expression, which is diminished in PPARα knockout mice (10). Despite the critical role of the fasting glucagon in the...
Mechanistically, SLC25A20 down-regulation promoted HCC growth and metastasis through suppression of fatty-acid oxidation. Altogether, SLC25A20 plays a critical tumor-suppressive role in carcinogenesis of HCC; SLC25A20 may serve as a novel prognostic factor and therapeutic target for patients with HCC...
Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim. Biophys. Acta 1807, 726–734 (2011). Article CAS PubMed Google Scholar Scharping, N. E. et al. The ...
Of note, spermidine supplementation also increased fatty acid oxidation (FAO) (Fig. 6h), partially reduced hepatic lipid species, and partially prevented hepatic steatosis, inflammation, and fibrosis in mice fed WDF (Fig. 5). Taken together, our results showed that spermidine supplementation ...
fatty acid β-oxidation pathway (GO: 0006635) in AT2 cells in ARDS is analyzed using human lung single-cell RNA sequencing datasets from people with fatal COVID-19 and controls (GSE171524, GSE171668). Expression score for each cell is calculated by averaging the expression of the gene ...
The n-3 PUFA stimulate PPAR target gene expression such as lipoprotein lipase (LPL), fatty acid transport protein (FTTP) and acyl-CoA synthase (ACS), thus enhancing the effects of n-3 PUFA on brain function [29]. In summary, the study showed that there is a relationship between gene ...
( 1992 ) Regulatory gene INO4 of yeast phospholipid biosynthesis is positively autoregulated and functions as a transactivator of fatty acid synthase genes ... HJ Schüller,R, Schorr,B, Hoffmann,... - 《Nucleic Acids Research》 被引量: 96发表: 1992年 Regulatory gene INO4 of yeast phospholipi...
Other engineered strains have deleted genes of the FAD pathway in order to prevent fatty acid degradation. Specifically, the deletion of fadD (fatty-acyl-CoA ligase) or fadE the first enzyme in the fatty acid oxidation cycle inhibit fatty acid catabolism, thereby leading to intracellular fatty ...