Gene ontology annotation analysis: Fatty acid metabolism.Bistra, B. NankovaRaj, AgarwalDerrick, F. MacFabeEdmund, F. La Gamma
inducegene transcription. Insulin stimulates SREBP-1c gene transcription, maturation, and activation (see detail under the section ‘Cholesterol Metabolism’). For elongation of palmitate tolonger chain fatty acids, palmitate is activated topalmitoyl CoAandelongasesadd two carbons to formstearic acid(C18...
APie chart of the distribution of BRD4-bound chromatin fragments.BAnalysis of BRD4 binding region distribution in chromatin.CGene enrichment pathways corresponding to BRD4-bound chromatin fragments.DGene enrichment analysis results of the GSH synthesis, iron metabolism, and lipid metabolism pathways fromKEG...
and MLX as novel targets of fatty acid-regulated gene expression. Keywords: gene transcription; hepatic fatty acid metabolismdoi:10.1080/17482970601069318Jump, DonaldBotolin, DanielaWang, YunXu, JinghuaChristian, BarbaraFood & Nutrition Research
B. Fuel feeds function: energy metabolism and the T-cell response. Nat. Rev. Immunol. 5, 844–852 (2005). Article CAS PubMed Google Scholar Jellusova, J. et al. Gsk3 is a metabolic checkpoint regulator in B cells. Nat. Immunol. 18, 303–312 (2017). Article CAS PubMed PubMed ...
Recent advances in the study of fatty acid metabolism involve several important attempts to develop and test ACC inhibitors. Selective inhibitors against ACC1 and ACC2, and specific ACC2 inhibitors, have been reported (35). However, when used in animals, the inhibitors should reduce fatty acid ...
Here, we highlight the complexity of cellular fatty acid metabolism in cancer, the various inputs and outputs of the intracellular free fatty acid pool, and the numerous ways that these pathways influence disease behavior.Background Cancer cells have distinctive metabolic phenotypes compared to normal...
The mechanisms which lead to the development of fatty liver, such as impaired fatty acid oxidation and increased de novo fatty acid synthesis, are regulated by hepatic gene transcription. n-3 LC-PUFA regulate lipid metabolism in the liver by acting as ligand activators of the transcription factor...
Engineering the pentose phosphate pathway and gluconeogenesis enables high-level production of free fatty acid (15.9 g l−1) from sole methanol. Preventing methanol-associated toxicity underscores the link between lipid metabolism and methanol tolerance, which should contribute to enhancing methanol...
This study determined the effect of CLA on the fatty acid (FA) metabolism of REC and expression of genes known to be modulated by FA. Cultured REC were incubated with c9t11, t10c12, and the structurally similar FA linoleic acid (LA), oleic acid (OA), and trans-vaccenic acid (TVA) ...