INHIBITION OF FATTY-ACID ELONGATION PROVIDES A BASIS FOR THE ACTION OF THE HERBICIDE, ETHOFUMESATE, We have studied the effects of ethofumesate on fatty acid synthesis in germinating pea seeds and developing barley leaves. Ethofumesate inhibited labelling... خالد بن عمر...
The biosynthesis of ‘unusual’ fatty acids with structures that deviate from the common C16 and C18 fatty acids has evolved numerous times in the plant kingdom. Characterization of unusual fatty acid biosynthesis has enabled increased understanding of e
We observed that the presence of microbes increases desaturation of palmitate (FA 16:0n-7) by SCD1 and elongation of γ-linoleic acid (FA 18:3n-6) to dihomo-γ-linolenic acid (FA 20:3n-6) by ELOVL5. Interestingly, SCD1 activity has been linked to various diseases including diabetes, ...
Condensing enzymes catalyze the first reaction in fatty acid elongation and determine the chain length of fatty acids accepted and produced by the fatty acid elongation complex. Although necessary for the elongation of all VLCFAs, known condensing enzymes cannot efficiently synthesize VLCFAs longer than...
Both fatty acid esters reduced croton oil-induced ear edema, decreasing neutrophil infiltration by inhibiting myeloperoxidase activity [28]. Moreover, some fractions of a Jatropha curcas extract that showed anti-inflammatory activity in RAW264.7 cells contain fatty acids such as octadecanoic acid methyl...
The plasma fatty acid composition was associated with the histological evidence of NASH. Increased synthesis of fatty acids is associated with NASH; insufficient intake of n-3 essential fatty acids and reduced elongation of fatty acids are associated with fibrosis in NASH. These features may help ...
very‐long‐chain fatty acidelongation mutantsynthetic lethalityElongation of long-chain fatty acids was investigated in yeast mutants lacking endogenous de novo fatty acid synthesis. In this background, in vitro fatty acid elongation was dependent strictly on the substrates malonyl-CoA, NADPH and a ...
Abulnaja KO, Tighe CR, Harwood JL (1992), Inhibition of fatty acid elongation provides a basis for the action of the herbicide ethofumesate on surface wax formation. Phytochemistry 4: 1155-1159Abulnaja KO, CR Tighe and JL Harwood (1992) Inhibition of fatty acid elongation provides a basis ...
Low erucic acid rapeseed (LEAR) is characterised by a near absence of very long chain fatty acids in the seed oil which has been correlated with a lack of acyl-CoA elongation activity. Here we show that the absence of acyl-CoA and ATP-dependent elongation activities in microsomes isolated fr...
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes ...