The interpretation of fate‐mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte‐macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of...
fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the...
In previous HSC fate mapping studies, the actual stem cell source that supplies hematopoiesis over the lifetime of the mouse, called tip HSCs, has remained elusive11,13,14,15. The defining criterion for such tip HSCs is that after label induction, constant labeling frequency is maintained by p...
The development of a vasculature is critical to the survival of the higher vertebrate embryo. Recent work has further shown that signals from vascular endothelial cells play an inductive role in differentiation of the Purkinje fiber network from cardiomyocytes (1) and the formation of pancreas from ...
Fate mapping studies reveal that adult microglia derive from primitive macrophages Microglia are the resident macrophages of the central nervous system (CNS) and have been implicated in the pathogenesis of many neurodegenerative and brain... F Ginhoux 被引量: 0发表: 2015年 Embryonic Microglia Derive...
cochleahair cellinner earRorbsupporting cellConditional loss-of-function studies are widely conducted using the Cre/Loxp system because this helps circumvent embryonic or neonatal lethality problems. However, Cre strains specific to the inner ear are lacking, and thus lethality frequently occurs even in...
and fates of various regions of the embryo. Vogt's fate mapping studies at the gastrula stage introduced embryologists to a very useful method of determining which portions of the embryo become which larval or adult structures and to modern investigations of amphibian gastrulation (Hardin, 1995)...
Comparison with studies in the chicken embryo shows that the rostrocaudal patterning of identified vestibular projection neuron groups is generally well conserved between avians and mammalians but that significant species-specific differences exist in the rostrocaudal limits of particular groups. This ...
Numerous studies, however, have also reported adult neurogenesis in the hypothalamus, a brain structure that serves as a central homeostatic regulator of numerous physiological and behavioral functions, such as feeding, metabolism, body temperature, thirst, fatigue, aggression, sleep, circadian rhythms, ...
The mouse midbrain-hindbrain constriction is centrally involved in patterning of the midbrain and anterior hindbrain (cerebellum), as revealed by recent genetic studies using mice and embryological studies in chick (reviewed in [1,2]). This region can act as an organizer region to induce midbrai...