The interpretation of fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of ...
fate-mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the...
Fate mapping studies were instrumental in deciphering the initial topographical relationships between the developing cephalic vesicles and the migratory NC cells. It turned out that the anteriormost part of the neural fold does not yield NC cells; those arise from the mid-diencephalon (corresponding to...
The intestinal epithelium has a fast cellular turnover and requires continuous regulated production of large numbers of cells in the right proportions.1The small intestinal epithelium is organized into crypts containing proliferating cells and villi with postmitotic differentiated absorptive enterocytes, secre...
Earlier studies identified prominent IFN-I signature in the choroid plexus as well as microglia isolated from the aging brain [4, 7, 8]. In bulk cortical tissue, conspicuous upregulation of IFN-I-induced genes (ISGs) was evident (Fig. S1a), in keeping with the elevated “innate immune re...
cochleahair cellinner earRorbsupporting cellConditional loss-of-function studies are widely conducted using the Cre/Loxp system because this helps circumvent embryonic or neonatal lethality problems. However, Cre strains specific to the inner ear are lacking, and thus lethality frequently occurs even in...
In previous HSC fate mapping studies, the actual stem cell source that supplies hematopoiesis over the lifetime of the mouse, called tip HSCs, has remained elusive11,13,14,15. The defining criterion for such tip HSCs is that after label induction, constant labeling frequency is maintained by ...
Previously reported Cre-based fate-mapping studies showed that I... Q Ma,B Zhou,WT Pu - 《Developmental Biology》 被引量: 378发表: 2008年 Basic Science Articles: Cellular Precursors of the Coronary Arteries Endothelium, VascularCoronary vessels develop from a primary vascular network that ...
(GAMS) used for fitting lineage-specific gene expression trends. Existing models could benefit from CellRank fate probabilities for assigning cells to lineages63. Further studies are needed to validate our new proposed markers for delta cell differentiation. We anticipate applying this framework to ...
11a). In parallel studies, we also tested the survival of GFP+ and DsRed+ cells when cultured in a suspension assay or when challenged with shear stress, to simulate the dynamics that cells encounter in the bloodstream. In both assays, GFP+ cells were significantly more resistant to cell ...