The interpretation of fate‐mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte‐macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of...
In previous HSC fate mapping studies, the actual stem cell source that supplies hematopoiesis over the lifetime of the mouse, called tip HSCs, has remained elusive11,13,14,15. The defining criterion for such tip HSCs is that after label induction, constant labeling frequency is maintained by p...
Mapping of Lunar Hydrogen According to the LEND Neutron Measurements Onboard the NASA LRO In this study we would like to present some preliminary estimations of hydrogen distribution along polar regions based on the LEND measurements of neutron ... A Sanin,I Mitrofanov,W Boynton,... - 《Develo...
Fate mapping studies reveal that adult microglia derive from primitive macrophages Microglia are the resident macrophages of the central nervous system (CNS) and have been implicated in the pathogenesis of many neurodegenerative and brain... F Ginhoux 被引量: 0发表: 2015年 Embryonic Microglia Derive...
Fate‐mapping analysis using Rorb‐IRES‐Cre reveals apical‐to‐basal gradient of Rorb expression in mouse cochleacochleahair cellinner earRorbsupporting cellConditional loss-of-function studies are widely conducted using the Cre/Loxp system because this helps circumvent embryonic or neonatal lethality ...
& Zhou, B. Genetic lineage tracing with multiple DNA recombinases: a user’s guide for conducting more precise cell fate mapping studies. J. Biol. Chem. 295, 6413–6424 (2020). Article CAS PubMed PubMed Central Google Scholar He, L. et al. Enhancing the precision of genetic lineage ...
Numerous studies, however, have also reported adult neurogenesis in the hypothalamus, a brain structure that serves as a central homeostatic regulator of numerous physiological and behavioral functions, such as feeding, metabolism, body temperature, thirst, fatigue, aggression, sleep, circadian rhythms, ...
Previous short-term fate mapping studies indicated that, once a cell is incorporated into the AER, its descendents remain within the AER. In addition, some preAER cells appear to become incorporated into the ventral ectoderm. In the present study, we used an inducible CreER/loxP fate mapping ...
Fate-mapping the mammalian hindbrain: segmental origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse... M Pasqualetti,C Diaz,JS Renaud,... - 《Journal of Neuroscience》 被引量: 76发表: 2007年 development/plasticity/repair fate-mapping the...
The mouse midbrain-hindbrain constriction is centrally involved in patterning of the midbrain and anterior hindbrain (cerebellum), as revealed by recent genetic studies using mice and embryological studies in chick (reviewed in [1,2]). This region can act as an organizer region to induce midbrai...