Thus, an expansion in the variety of fate-mapping mouse models has occurred to answer fundamental questions about the immune system. These models are also being combined with new genetic tools to study cancer, infection, and autoimmunity. In this review, we summarize different types of fate-...
mapping studies depends upon multiple assumptions: (i) that expression of cre recombinase has no effect on monocyte-macrophage homeostasis, (ii) that tamoxifen is a neutral agonist, (iii) that life in an SPF animal facility reflects the normal life course of a mouse, and (iv) that the C57...
Bladder tissue engineering: Tissue regeneration and neovascularization of HA-VEGF-incorporated bladder acellular constructs in mouse and porcine animal models Successful tissue engineering requires appropriate recellularization and vascularization. Herein, we assessed the regenerative and angiogenic effects of po...
Thus, this next generation of fate mapping is poised to help us more deeply comprehend how cell identity is regulated within the context of a developing organism。万事俱备,只欠行动?these high-resolution, dynamic models will aid in building a quantitative understanding of the rules governing ...
For delta cell development, we showed how gene expression can be correlated with fate probabilities to identify putative driver genes. Alternatively, drivers could be identified through statistical tests on the parameters of the generalized additive models (GAMS) used for fitting lineage-specific gene ...
CellRank 2: unified fate mapping in multiview single-cell data Philipp Weiler, Marius Lange, Michal Klein, Dana Pe’er & Fabian Theis Nature Methods volume 21, pages 1196–1205 (2024)Cite this article 24k Accesses 83 Altmetric Metrics details Abstract Single-cell RNA sequencing allows us to...
Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells These models traced efficiently monocytes and granulocytes, but no lymphocytes or tissue dendritic cells. Using these models, we precisely quantified the ... Z Liu,Y Gu,S Chakarov,... - 《Cell》 被引量: 0发表: 2019年 ...
We used three-dimensional models to map the fate of larval tissues of O. minuta through metamorphosis and provide the first detailed account of larval tissue reorganization at metamorphosis of a glass sponge larva. Larvae settle on their anterior swimming pole or on one side. The multiciliated ...
Fate Mapping Identifies the Origin of SHF/AHF Progenitors in the Chick Primitive Streak 来自 NCBI 喜欢 0 阅读量: 22 作者:E Camp,S Dietrich,A Münsterberg 摘要: Heart development depends on the spatio-temporally regulated contribution of progenitor cells from the primary, secondary and anterior ...
Resource FateMappingviaMs4a3-ExpressionHistoryTraces Monocyte-DerivedCells GraphicalAbstract Highlights dMs4a3isspecificallyandtransientlyexpressedbyGMPsin thebonemarrow dMDPsdonotarisefromGMPsanddonotgiverisetocMoPs dMs4a3-basedmodelsspecificallyandefficientlyfatemap monocytesandgranulocytes dDistinguishmono...