Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated in the hippocampus of patients with MDD and mouse models of depression. Suppressingexpression in the mouse hippocampus results in depression-like behaviors in adult mice, whereas...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The fat mass and obesity–associated protein (FTO) has been shown to be involved in obesity; however, its role in NAFLD and the underlying molecular mechanisms r
Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neurons (D2 MSNs) of mice regulate the excitability of these cells and control their striatopallidal globus pallidus external (GPe) projections. Lack of FTO in D2 MSNs ...
Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intake and body weight. Although the proteasome system ...
Genome wide association studies undoubtedly linked variants of the fat mass and obesity-associated protein (FTO) to obesity. To date, however, knowledge on the mechanisms coupling variants in the intron of the FTO gene to its expression or enzymatic activity to alter metabolism remains scarce. Unti...
Recent studies on the management of obesity are centered on the ability of small compounds to modulate fat mass and obesity-associated protein (FTO). This ... A Idoko,EJ Parker,OU Njoku - 《Tropical Journal of Natural Product Research》 被引量: 0发表: 2024年 The fat mass and obesity-asso...
Although bi-directional relationships between high body mass index (BMI) and affective symptoms have been found, no study has investigated the relationships across the life course. There has also been little exploration of whether the fat mass and obesity-associated (FTO) rs9939609 single-nucleotide...
(%)African American90 (55)Non-Hispanic white65 (40)Other9 (6)Weight, mean (SD), kg87.3 (18.7)Body mass index, mean (SD)*30.2 (6.1)Obesity status, No. (%)Not overweight or obese34 (21)Overweight57 (34)Obese73 (45)Alcohol intakeDrink any alcohol, No. (%)73 (45)Servings/wk ...
There are several genes linked with ALS, such as SOD1, TARDBP, FUS, C9ORF72, ALS2, SETX, SPG11, VAPB, ANG, and OPTN. A recent study implicated fat mass and obesity-associated (FTO) gene with the pathogenesis of the disease. This warranted further investigation. Therefore, a list of ...
Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intake and body weight. Although the proteasome system ...