Here, we report that expression of the fat mass and obesity associated gene (FTO), an RNA demethylase, is downregulated in the hippocampus of patients with MDD and mouse models of depression. Suppressingexpress
Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neurons (D2 MSNs) of mice regulate the excitability of these...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The fat mass and obesity–associated protein (FTO) has been shown to be involved in obesity; however, its role in NAFLD and the underlying molecular mechanisms r
MCE 站:Fat Mass and Obesity-associated Protein 品牌:MedChemExpress (MCE) 概述:脂肪量和肥胖相关基因 (FTO) 是 Fe (II) 和氧化戊二酸依赖性 AlkB 双加氧酶家族的成员,与肥胖和智力障碍有关。先前的研究表明,FTO 在脂肪生成和能量稳态中发挥着关键作用。 FTO缺陷的小鼠表现出出生后生长迟缓和食物摄入量减少...
Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intake and body weight. Although the proteasome system ...
英文名字 Fto (Fat mass and obesity-associated protein) Antibody 供应商 Abgent 产品货号 A-AN1187 产品报价 ￥3685/100 ul 产品说明书 点击查看 购买方式 产品新闻 背景资料 The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be sign...
Although bi-directional relationships between high body mass index (BMI) and affective symptoms have been found, no study has investigated the relationships across the life course. There has also been little exploration of whether the fat mass and obesity-associated (FTO) rs9939609 single-nucleotide...
4 Both prepregnancy body mass index (BMI) and weight gain during pregnancy are positively associated with gestational insulin resistance,5, 6, 7 and obesity is a risk factor for gestational diabetes mellitus.8 Despite the impact of body weight and obesity on gestational insulin resistance, there ...
Genome wide association studies undoubtedly linked variants of the fat mass and obesity-associated protein (FTO) to obesity. To date, however, knowledge on the mechanisms coupling variants in the intron of the FTO gene to its expression or enzymatic activity to alter metabolism remains scarce. Unti...
ALKBH7 is a nonheme Fe(II)- and α-ketoglutarate (α-KG)2-dependent dioxygenase, one of the nine human homologs of AlkB family (termed as ALKBH1–8 plus fat mass and obesity-associated protein (FTO)) (9, 10). The Fe(II)/α-KG-dependent dioxygenases play diverse biological roles, ...