Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice follow
Obesity remains a risk-factor for the early onset of many age-related diseases. Weight loss can reduce blood pressure, insulin resistance, as well as the risk for cancer and cardiometabolic diseases49,50,51. When assessing whether changes in weight were associated with the change in biological ...
Material and methods: In eight healthy volunteers the portal flow in the fasting state was measured using phase-contrast MRI. Then a standardized meal (600 kcal) was given. After this meal the same measurement was repeated every five... I Sobels 被引量: 0发表: 2011年 ...
Such reductions may account for the reported improvements in homeostatic model assessment (HOMA) insulin resistance, i.e., hepatic insulin resistance with IER described below [12,13], (see Section 4.4) but require further study. In contrast, short term fasting studies raise the...
Manganese-enhanced MRI (MEMRI) provides high contrast structural and functional d... V Bouilleret,L Cardamone,RL Ying,... - 《J Neurotrauma》 被引量: 46发表: 2009年 Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase Copper, like iron...
We randomized 131 patients with HER2-negative stage II/III breast cancer, without diabetes and a BMI over 18 kg m−2, to receive either a fasting mimicking diet (FMD) or their regular diet for 3 days prior to and during neoadjuvant chemotherapy. Here we show that there was no ...
which is the voluntary renouncement of food for a defined period and which results in distinct metabolic changes, i.e., pronounced lipolysis, decreased insulin secretion, increased insulin sensitivity, gluconeogenesis, and production of ketone bodies [23]. Periodic fasting, in contrast to intermittent...
In a study examining the relationship between glucose level and cognitive function rather than the development of dementia, cognitive function was not found to be related to FBG or insulin resistance in young subjects20. By contrast, a cross-sectional study with more than 10,000 Chinese subjects ...
(Fig.5a–c). Consistent with the hypothesis that hyperinsulinemic signaling drives NAFLD development and progression, 7 weeks following tamoxifen treatment PerIRKO+/−had substantially lower hepatic lipid content and plasma ALAT (Fig.5d, e). Surprisingly, and in contrast to when the IR was ...
This effect is in contrast with the activation of SIRT1 by CR in many other peripheral tissues. For example, in the liver, SIRT1 activation reduces IGF-1 serum levels [16], while IGF-binding protein-1 (IGFBP-1) levels are significantly increased in SIRT1 KO mice [17]. On the other ...