Farnesyl pyrophosphate synthase (FPPS) is a key enzyme in the mevalonate pathway. Our previous studies have indicated that cardiac-specific overexpression of FPPS induces cardiac hypertrophy and dysfunction in mice, and inhibition of FPPS prevents angiotensin (Ang) II-induced hypertrophy in ...
Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS). Biochem/physiol Actions Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of...
To better understand how these hydrocarbons are biosynthesized, we characterized the farnesyl pyrophosphate (FPP) synthase (FPPS) enzyme of R. setigera. An isolated 1465-bp cDNA clone contained an open reading frame spanning 1299-bp encoding a protein with 432 amino acid residues. Expression of ...
These findings point to that FPPS might be a potential target in preventing H9c2 cells from HR-induced injury. 展开 关键词: Farnesyl pyrophosphate synthase Hypoxia/reoxygenation Reactive oxygen species Rac1 DOI: 10.1002/cbin.10795 年份: 2017 ...
Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral an... Here we report a new full-length cDNA encoding farnesyl diphosphate synthase from Hedychium coronarium. The open reading frame for full-length Hc...
synthase gene that was expressed in the hop luplin gland in a specific manner was elucidated based on the genomic DNA of the hop farnesyl pyrophosphate synthase gene having the nucleotide sequence set forth in SEQ ID NO:2, the cDNA of the hop farnesyl pyrophosphate synthase gene having the nu...
Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development Recent studies have validated \\{FPPS\\} as a molecular target of bisphosphonates for drug development against tumors as well as human pathogens. The ... Manoj,K.,Dha...
GW24-e2384 The role of farnesyl pyrophosphate synthase in angiotensin II-induced cardiac fibrosisThis study reveals FPPS elevation in Ang II-induced cardiac fibrosis model both in vivo and in vitro model. The inhibition and knockdown of FPPS reduces RhoA activation by diminishing ...
N6-isopentenyladenosine (i6A), a modified nucleoside belonging to the cytokinin family, has shown in humans many biological actions, including antitumoral effects through the modulation of the farnesyl pyrophosphate synthase (FPPS) activity. To investigate the relationship between i6A and FPPS, we ...
Abstract Farnesyl pyrophosphate synthase (FPPS \{EC\} 2.5.1.10) catalyzes the production of farnesyl pyrophosphate (FPP), which is a key precursor for many sesquiterpenoids such as floral scent and defense volatiles against herbivore attack. Here we report a new full-length cDNA encoding farnesyl ...