Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer.doi:10.2217/pme-2016-0058ükrü TüzmenGalen HostetterAprill WatanabeCumhur EkmekiPatricia E CarriganIshaiahu ShechterOlli KallioniemiLaurence J MillerSpyro Mousses...
产品名称:farnesyl diphosphate synthase抑制剂(Alendronate sodium hydrate) 英文名称:Alendronate sodium hydrate 产品货号:M01602 产品规格:1mL(10mM)|100mg|500mg Alendronate sodium hydrate是一种farnesyl diphosphate synthase抑制剂,IC50值为460nM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途!
2.04.3.1.1 Farnesyl diphosphate synthase (i) Enzymology The most widely occurring and the most extensively studied prenyltransferase is FPP synthase (geranyltranstransferase (EC 2.5.1.10)). This enzyme occupies a particularly important branch point on the pathway of isoprenoid biosynthesis as...
药品名称 Farnesyl diphosphate 分子靶点 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha;Protein farnesyltransferase subunit beta;GTPase KRas;2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase;Farnesyl pyrophosphate synthase;Ditrans,polycis-undecaprenyl-diphosphate 药物类型 Small ...
Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors transferase (FTase), the enzyme responsible for protein farnesylation, has become a key target for the rational design of cancer chemotherapeutic agents. The....
transferase was also expressed inE. coli,using cDNA clones encoding both the a and b subunits. The methods used were similar to those published (Omer, C. et al., (1993), Characterization of recombinant human farnesyl protein transferase: Cloning, expression, farnesyl diphosphate binding, and ...
EC number 2.5.1.29 Systematic name trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase Recommended name farnesyltranstransferase Synonyms farnesyltransferase geranylgeranyl diphosphate synthase geranylgeranyl pyrophosphate synthase geranylgeranyl pyrophosphate synthetase geranylgeranyl-PP synthetase ...
Sagami, H.; Korenaga, T.; Ogura, K.: Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate. J. Biochem., 114, 118–121 (1993) PubMed CAS Google Scholar Wiedemann, M.; Misawa, N.; Sandmann, G.: Purification and enzymati...
EC number 3.1.7.6 Systematic name (2E,6E)-farnesyl-diphosphate diphosphohydrolase Recommended name farnesyl diphosphatase Synonyms...
Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue The crystallographic structure of acetyl-Cys-Val-Ile-selenoMet-COOH and alpha-hydroxyfarnesylphosphonic acid (alphaHFP) complexed with rat farnesyl protein... CL Strickland,WT Windsor,R Syto...