which can be labeled with radionuclides for theranostic applications. We present the first-in-humans results using177Lu-FAP-2286 for peptide-targeted radionuclide therapy (PTRT).Methods: PTRT using177Lu-FAP-2286 was
FAP-2286是3B-Pharmaceuticals GmbH公司研发的含有环状七肽核心的靶向FAP的多肽。临床前评估显示,FAP-2286对FAP重组蛋白和成纤维细胞表面表达的FAP都表现出高度亲和力,并且比FAPI-46具有更长的肿瘤滞留和抑制时间。动物生物分布研究表明,68Ga-F...
Further work should be undertaken to define the settings where 68Ga-FAP-2286 PET may inform clinical decision making, and which pts may benefit from FAP-targeted radioligand therapy. Clinical trial information: NCT04621435.doi:10.1200/jco.2022.40.16_suppl.3059T. Hope...
In addition, the ability to measure the effect of an inhibitor in clinical trial subjects would enhance the understanding of the relationship between pharmacokinetics and pharmacodynamics; an aspect that is vital in selecting an appropriate dose regimen to balance drug efficacy and safety. In this ...
FAP-2286 was the first peptide-targeted radioligand therapy (PT-RLT) targeting FAP to enter clinical development together with the respective imaging agent, making it the most advanced radioligand therapy in its class. It is currently being tested in a phase 1 ...
The combination of CPP-1X and sulindac prevented more than 90% of subsequent pre-cancerous sporadic adenomas compared to placebo in a Phase III clinical trial conducted in sporadic large bowel polyps patients.
Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial. Ann Oncol, 2021,32(1):120–121 Article CAS PubMed Google Scholar Fan MH, Zhu Q, Li HH, et al. Fibroblast Activation Prot...
The study was approved by the Chinese Ethics Committee of Registering Clinical Trials (ChiECRCT20210617) and registered on the Chinese Clinical Trial Registry (ChiCTR2200059004). Consent to participate Informed consents were obtained from all individual participants included in the study. Consent for publ...
Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy Article Open access 24 May 2022 Introduction The fibroblast activation protein (FAP) is a membrane serine protease expressed by fibroblasts. FAP has recently emerged as one of the most promisin...