Background Transthyretin-associated amyloidosis (ATTR) is the commonest cause of hereditary amyloidosis. Age at onset is 50–60 years with average life-expectancy of 7–14 years. Lumbar spinal stenosis also presents in late middle-age; related to disc degeneration, spondylolisthesis and age-related...
The most serious complication of FMF is amyloidosis.Serum amyloid Ais anacute phase reactantthat can deposit in many organs, including the kidney, leading to organ failure. Beforecolchicinetherapy, end-stage renal disease occurred in many FMF patients by the age of 40 years. Oral colchi...
attacks last less than 24 hours. Renal disease from AA amyloidosis is rare occurring in less than 2% of patients. There are several patients with clinical overlap with Muckle Wells syndrome (MWS) prompting many investigators to conclude that FCAS, ...
Disease-modifying agentTafamidisLiver transplantationHereditary ATTR amyloidosisFamilial amyloid polyneuropathyAmyloidosis neuropathyCarpal tunnel syndromeCardiomyopathyRed-flag symptom clustersHereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal...