Familial amyloid polyneuropathy is a dominantly inherited neuropathic form of amyloidosis caused by the hepatic production of a mutant transthyretin (TTR).32-34 Because TTR is produced almost exclusively by the liver, liver transplantation eliminates the underlying cause of the disease: production of an...
The most serious complication of FMF is amyloidosis.Serum amyloid Ais anacute phase reactantthat can deposit in many organs, including the kidney, leading to organ failure. Beforecolchicinetherapy, end-stage renal disease occurred in many FMF patients by the age of 40 years. Oral colchic...