Theocharis S, Klijanienko J, Giaginis C, Alexandrou P, Patsouris E, Sastre-Garau X. FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival. J Cancer Res Clin Oncol. 2012;138:1369-77....
signaltransducersandactivatorsoftranscription,JAK/STAT)途径,也可通过Ras途径转 导信号.另外,离子通道(如机械敏感性K通道),牵拉敏感的转导蛋白(transduc— er)及整合素超家族亦可能开启一组共同的信号通路.本文就整合素超家族中的Src族 激酶及黏着斑激酶(focaladhesionkinase,FAK)在心肌肥大信号转导中的作用的最新 ...
为非受体蛋白酪氨酸激酶是整合素信号的早期调控因子,在黏着斑FAK—Src信 号复合物的形成在心肌肥大的信号 转导通路中起重要作用.本文综述了Src与FAK的相互作用及其在心肌肥大信号 转导中作用研究的最新进展. 关键词:黏着斑激酶;Src;心肌肥大;细胞信号转导
the mRNA level of TGF β1，NOX4，FAK ，Src and α-SMA in treatment groups by RT-PCR were decreased significantly （F =5.546，4.285，6.626，3.911，5.914，all P ＜0.05）.Conclusion ：Lumbrokinase attenuates renal interstitial fibrosis of UUO rats.Its mechanism is related to the ...
These changes have been attributed to the regulation of cytoplasmic tyrosine kinases, FAK and Src, by integrins [9], [10]. Both FAK and Src can bind directly to the integrin β tail [6], [16]. Thus, Tac-β1 may titrate FAK and/or Src from endogenous β tails and prevent their ...
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression o
FAK由受体酪氨酸激酶(RTK)、细胞内pH变化(H+)、整合素、G蛋白偶联受体(GPCR)和细胞因子受体激活,通过对ARP2/3、RHO鸟嘌呤核苷酸交换因子(RHOGEF)、talin或cortactin以及SRC或PI3K介导的信号传导的影响来增加细胞运动性。 (图源:[2]) FAK在多种晚期的细胞和实体...
用Src阻断剂-PP2阻断Src,用MAPK阻断剂-UO126阻断MAPK,观察Src或MAPK被阻断后对ErbB2诱导的细胞移动和细胞转化的影响。结果:感染后ErbB2在FAK+/+细胞中稳定表达和激活。PP2抑制ErbB2诱导的FAK磷酸化以及ErbB2诱导的细胞移动。UO126阻断ErbB2诱导的MAPK磷酸化以及ErbB2诱导的细胞锚定依赖性生存-细胞转化。结论:ErbB2...
To study the mechanism whereby Tac-β1 inhibits cell spreading, we examined the effect of Tac-β1 on early signaling events following integrin engagement namely FAK and Src signaling. We infected primary fibroblasts with adenoviruses expressing Tac or Tac-β1 and found that Tac-β1 prevented FAK...
signaltransducersandactivatorsoftranscription,JAK/STAT)途径,也可通过Ras途径转 导信号.另外,离子通道(如机械敏感性K通道),牵拉敏感的转导蛋白(transduc— er)及整合素超家族亦可能开启一组共同的信号通路.本文就整合素超家族中的Src族 激酶及黏着斑激酶(focaladhesionkinase,FAK)在心肌肥大信号转导中的作用的最新 ...