Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.James M. MurphyDepartment of Biochemistry and Molecular BiologyHyeonsoo ParkSsang-Taek Steve Lim生物学前沿:英文版Murphy, J.M.; Park, H.; Lim, S.-T.S. FAK ...
FAK通常以非活性形式存在于胞质中,此时FERM结构域直接与激酶结构域相结合,抑制其催化活性。 目前,FAK家族共有两个成员,即PTK2(FAK)和Pyk2。其中,Pyk2蛋白与FAK蛋白有48%的相同氨基酸,这两种激酶都不含SH2和SH3结构,属于非受体酪氨酸激酶。FAK几乎表达于所有的细胞和组织类型,在睾丸和脑中高表达。由于在肿瘤向恶...
结论阿霉素可能通过激活FAK、Pyk2磷酸化导致肾病的发生;泼尼松能抑制FAK、Pyk2激活,降低阿霉素肾病大鼠蛋 白尿,改善足突病变,从而保护肾小球滤过屏障。 Abstract:Objective To investigate the effects of prednisone on the expressions of FAK and Pyk2 in the kidneys of rats with adriamycin-induced nephritis. M...
A. (2005). FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3. Biochem Biophys Res Commun 337, 641-6.Bongiorno-Borbone L, Kadare G, Benfenati F, Girault JA. 2005. FAK and PYK2 interact with SAP90/PSD-95-associated protein-3. Biochem Biophys Res Commun 337:641-646....
生化机理双粘着斑激酶(FAK)和富含脯氨酸的酪氨酸激酶2(PYK2)抑制剂(IC50分别为2和11 nM)。促进成骨细胞募集和活动,并刺激去卵巢大鼠的骨形成。 公司简介 北京雅安达生物技术有限公司依托*重点实验室建立,是由具有资深生命科学、生物技术背景及留学归国人员共同创办的高新技术企业。
Adhesion signaling between epithelial cells and the extracellular matrix plays a critical role in maintaining tissue homeostasis and the response to tissue damage. Focal adhesion kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine kinases that mediate adhesion signaling to promote cell pr...
FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation James M. Murphy, Kyuho Jeong, Yelitza A. R. Rodriguez, Jung-Hyun Kim, Eun-Young Erin Ahn & Ssang-Taek Steve Lim Scientific Reports volume 9, Article number: 7617 (...
周皮细胞Gas6敲除也可抑制FAK缺失造成的肿瘤生长和血管生成。有文献报道,当FAK缺失时,其家族成员Pyk2会进行补偿。结果也表明敲除周皮细胞FAK上调p-Pyk2的表达。使用抑制剂也得到相同的结论 (fig.3j),揭示p-Pyk2在内源性Gas6/Axl调控中...
PF-431396是双PYK2/FAK抑制剂,IC50分别为11nM和2 nM。A dual inhibitor of FAK (focal adhesion kinase) and PYK2. 查看阿拉丁官网此产品相关对应页面:https://www.aladdin-e.com/zh_cn/P127348.html 717906-29-1;PF-431396;PF 431396;PF431396 查看全部 公司简介 上海阿拉丁生化科技股份有限公司是A股上市...
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively. Quick View A13037 Conteltinib multi-kinase inhibitor Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK...