(Y397)、PTEN的表达与胃腺癌分化程度、浸润深度、淋巴结转移及TNM分期有关(P<0.05),与年龄、性别无关(P>0.05);PTEN与FAK、p-FAK(Y397)在胃腺癌中的表达呈负相关(r=-0.514,-0.572;P<0.05).FAK与p-FAK(Y397)呈正相关(r=0.539;P<0.05).结论:胃腺癌中存在FAK和p-FAK(Y397)表达上调,PTEN表达下调,...
目的:研究粘着斑激酶(FAK),磷酸化粘着斑激酶(p-FAK(Tyr397)),与张力蛋白同源的第10号染色体丢失的磷酸酶基因(PTEN)在胃腺癌组织中的表达及其与胃腺癌发生发展,临床病理特征之间的关系. 方法:采用免疫组织化学法检测FAK,P-FAK(Tyr397)和PTEN在100例胃腺癌和30例切缘正常组织中的表达. 结果:... 查看全部>>关...
Monoclonal antibodies against phospho-FAK (p-FAK; Tyr397) (RLP0739), Src, filamin A, ROCK and cofilin were from Ruiying Biological (Shuzhou, China). ROCK inhibitor (Y27632) was purchased from Selleckchem (Houston, TX, USA). Inhibitors of Src (PP2) and FAK (PF573228), and TRTIC-...
38. Xing Y, Hogge DE. Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110delta subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors. Leuk Res. 2013;37:697–704. 39. Qu Y, Wu X, ...
Thomas J. Parsons for the generous gift of p125Fak cDNA. We thank Y. LeMarchand-Brustel and J. F. Tanti for helpful discussions, and I. Mothe, P. Gual, and R. Quarck for critical reading of the manuscript. We acknowledge J. Duch for secretarial assistance....
TA4)信号通路;④过氧化物酶体激活物受体(PPAR)一^y通过抑制激活蛋白一1通 路与抑制坏死因子(TNF)一d途径调节ET一1基因的表达;⑤胞质非受体酪氨酸激 酶的细胞因子受体,主要启动詹纳斯激酶/信号传导蛋白转录激活因子(Januskinase/ 收稿日期:2006—08—10 ...
Grb2.Sos 信号复合体的相互作用.Tyr.397 磷酸化产生Src 家SH2 域的高亲合力的Sre 结 合位点,从而FAK.Src 信号复合物形成.Franchini 等在压力负荷致心肌肥大的左心室 FAK 免疫沉淀物中检测到p60c.Sre 量的增加,提示压力负荷可同时引起FAK 和Sre 酪 ...