The contents of cytochrome b, suggested as the terminal component of the oxidase electron transport chain, and FAD, the hypothetical proximal component of the chain, were determined in patients and in carriers. Cytochrome b showed the typical behaviour of x-linked CGD: total absence in patients,...
A. The reaction driven by the FAD-dependent phenylalanine oxidase IL-4I1, leading to the generation of H2O2 (yellow highlight, right), is depicted. B. IL-4I1 activity (RFU, mean ± SD, n = 4) in the presence of either rSmNPP5 (red symbols) or control protein (BSA, ...
Lysine-specific demethylase-1 (LSD1, also known as KDM1A) is a member of the flavin-containing amine oxidase family that, in general, represses transcription by removing the methyl group from mono-methylated and di-methylated lysine 4 of histone H3 (H3K4)6. LSD1 is also involved in the d...
Erv2p is an FAD-dependent sulfhydryl oxidase that can promote disulfide bond formation during protein biosynthesis in the yeast endoplasmic reticulum. The structure of Erv2p, determined by X-ray crystallography to 1.5 Å resolution, reveals a helix-rich dimer with no global resemblance to other kn...
SmNPP5 does not inhibit IL-4I1 reactivity.A. The reaction driven by the FAD-dependent phenylalanine oxidase IL-4I1, leading to the generation of H2O2(yellow highlight, right), is depicted.B. IL-4I1 activity (RFU, mean ± SD,n = 4) in the presence of either rSmNPP5 (red...
Direct electron transfer (DET) Glucose oxidase 1. Introduction The history of the development of glucose sensors goes hand-in-hand with the history of discovery and engineering of glucose-sensing enzymes [1]. The first reported electrochemical glucose sensor was developed by the combination of gluco...
The C-terminal domain was predicted to contain six transmembrane α-helices with distant homology to yeast ferric reductases and to mammalian NADPH oxidase among others (2). Thus, collectively, the transmembrane domains of the Steap, ferric reductase, and NADPH oxidase protein families place each ...
As gut metabolite alteration has been linked to a defect in mucosal integrity and immune balance19,21, we then asked whether the gut epithelium might be exposed to a proinflammatory environment due to metabolic disorders. Hematoxylin-eosin (HE) staining of ileum tissue sections from both WT and ...
The N-terminal FAD-binding domain (residues 3–111) is colored in blue, the NADH-binding domain (residues 112–238) is shown in yellow, the C-terminal FAD-binding domain (residues 239–317) is depicted in light blue, and the C-terminal domain (residues 318–404) is colored in red. ...
wherein the promoter is operatively linked to the region; wherein the region encoding an Aβ-containing protein comprises DNA encoding an APP protein selected from the group consisting of APP695, APP751 and APP770 comprising at least one point mutation associated with a familial Alzheimer's disea...