You may need factor Xa inhibitors for a set period of time or the rest of your life. It depends on what caused your blood clot in the first place. Your doctor will also consider your age, other health conditions, and what might happen if they raise your chances of bleeding for a long...
Inhibitors of factor Xa; for example 3-(4-tert-butylbenzoyl)amino-N-(4-methoxyphenyl)-2-thiophenecarboxamidedoi:US20020049234 A1This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, ...
Factor Xa inhibitors (i.e., apixaban, rivaroxaban) No effect on pharmacokinetics of coagulation factor Xa (recombinant), inactivated-zhzo Heparin May interfere with the anticoagulant effect of heparin Avoid use of coagulation factor Xa (recombinant), inactivated-zhzo prior to heparinization; use...
The present invention is directed to compounds represented by formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions ...
INHIBITORS OF FACTOR XAanticoagulantFXaprothrombinaseNovel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted ...
Factor Xa inhibitors 专利名称：Factor Xa inhibitors 发明人：Al-Obeidi, Fahad,Lebl, Michal,Ostrem, James A.,Safar, Pavel,Stierandova, Alena,Strop,Peter,Walser, Armin 申请号：EP03021617.0 申请日：19950425 公开号：EP1384725A3 公开日：20070221 专利内容由知识产权出版社提供 摘要：The invention ...
This Invention describes amino acid derivatives that are inhibitors of factor Xa serinaproteasa.The Invention also describes pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, processes for the preparation of the compounds, and...
This Invention relates to amino acid derivatives that are inhibitors of factor Xa serinaproteasa.The Invention also describes pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, processes for preparing the compounds, and Methods...
Factor Xa inhibitory compounds which are not large polypeptide-type inhibitors have also been reported including: Tidwell, R. R. et al., “Strategies for Anticoagulation With Synthetic Protease Inhibitors. Xa Inhibitors Versus Thrombin Inhibitors”, Thromb. Res., 19, 339-349 (1980); Turner, A....
The last five years have seen an explosion of research into inhibitors of Factor Xa as potential antithrombotic agents. Aventis Pharma was a participant in... HW Pauls,WR Ewing - 《Current Topics》 被引量: 12发表: 2001年 Antibodies to factor Xa inhibitors and methods of use thereof PROBLEM...