factor Xa inhibitorfondaparinuxidraparinuxLY517717otamixabanrazaxabanrivaroxabanYM150Novel anticoagulants to replace unfractionated , low molecular weight and vitamin K antagonists, are needed urgently. factor Xa is an attractive target for drug development because of its position at the convergence of ...
Factor XaAnticoagulantsAdministration, OralDrug InteractionsWarfarin and heparin are the traditional mainstay anticoagulant therapies for treating thromboembolic disease. These drugs, with a documented history of utility, also have inherent difficulties in usage; in particular, the complicated monitoring and ...
Visit the website of the company that makes your factor Xa inhibitor. They may have an alert card you can download and print. Talk to your doctor orpharmacistfor more information.
Dosage based on the specific factor Xa inhibitor, dosage of the factor Xa inhibitor, and time since the patient's last dose of the factor Xa inhibitor. (See Table 1.)Table 1. Factor Xa (Recombinant), Inactivated-zhzo Dosage Based on Apixaban or Rivaroxaban Dose and Timing1 Factor Xa ...
Comparative Studies of an Orally-active Factor Xa Inhibitor, YM-60828, with other Antithrombotic Agents in a Rat Model of Arterial Thrombosis We examined the antithrombotic activity of a novel synthetic inhibitor of factor Xa, YM-60828, in an electrically-induced carotid artery thrombosis model i....
48-52 Unlike UFH and LMWH, these drugs do not require AT for FXa-inhibitory activity. Rivaroxaban (Xarelto) is a direct inhibitor of factor Xa with approximately 80% bioavailability in people after oral administration.53 The ROCKET AF study in humans compared rivaroxaban with w...
XVIII Antithrombin III 58 0.15–0.40 (2.5 nM) Inhibitor of thrombin and factors IXa and Xa. XIX Thrombomodulin 100 — Bound to α-thrombin it activates C to Ca. XX Protein S — — Bound to Ca it facilitates inhibition of thrombin generation. Formation of the clot is due to th...
Apixaban, an oral direct factor Xa inhibitor: awaiting the verdict. Expert Opin. Investig. Drugs 17, 1937–1945 (2008). Article CAS PubMed Google Scholar Piccini, J. P., Patel, M. R., Mahaffey, K. W., Fox, K. A. & Califf, R. M. Rivaroxaban, an oral direct factor Xa ...
factor Xa is an attractive target for... D Kubitza,S Haas - 《Expert Opinion on Investigational Drugs》 被引量: 231发表: 2006年 Biochemical and Pharmacological Characterization of YM-60828, a Newly Synthesized and Orally Active Inhibitor of Human Factor Xa YM-60828 was found to potently ...
(1993) “Structure of human des(145) factor Xa at 22 Å resolution” Journal Mol. Biol. 232:947-966. Perzborn et al. (2005) “In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct factor Xa inhibitor” J. Thromb. Haemost. 3:514-521. ...