Noun1.factor X- coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors prothrombinase clotting factor,coagulation factor- any of the factors in the blood whose actions are essential for blood ...
Another SP family member, activated coagulation factor X (FXa), binds to tissue factor to initiate the conversion of prothrombin to thrombin in the clotting cascade13. Direct FXa inhibitors (rivaroxaban, apixaban, edoxaban, and betrixaban), as well as an indirect inhibitor (fondaparinux), have bee...
The clotting cascade is activated in three ways: (i) promoting the activation of platelets, (ii) promoting the activation of clotting factors, and (iii) promoting the aggregation and adhesion of platelets and red blood cells. For example, the positive charges of chitosan (CS) attract red ...
(in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of ...
2 Factor Xa inhibitors Factor X is one of the vitamin K dependent serine proteases involved in blood coagulation cascade, which displays an important role in the coagulation network at the common pathway that connects both the tissue factor-activated extrinsic pathway and the surfa...
This Invention relates to amino acid derivatives that are inhibitors of factor Xa serinaproteasa.The Invention also describes pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, processes for preparing the compounds, and Methods...
Coagulation factors are specialized proteins in blood that regulate the clotting process to prevent excessive bleeding from an injury and dissolution of the clot once the bleeding is arrested. Factor Xa (Fxa) is an enzyme that plays a vital role in initiating the coagulation cascade. Apixaban and...
Factor VIII:C deficiency in the mammal is bypassed by infusion of a synergistic mixture of a phospholipid and Factor Xa so that the cascade process of blood clotting may continue. The proportions of phospholipid and Factor Xa in the mixture are critical as too little Xa has no effect while ...
Blood clotting in response to vascular injury requires the activation of zymogens in the coagulation cascade, in which thrombin and FXa are key players. FXa, a trypsin-like serine protease, functions at the convergence of the extrinsic and intrinsic coagulation pathways. Thus, it plays a central...
Blood coagulation Factor X occupies a central role in the clotting cascade. It can be activated by either Factor VIIa-tissue factor (extrinsic tenase) or by Factor IXa-VIIIa-phospholipid (intrinsic tenase). Once activated, it participates in formation of the prothrombinase complex, composed of Fa...