In general, results obtained on the same samples are similar; however, discrepancies can be seen in plasmas which contain activated factors of the coagulation cascade. These factors make the clotting times obtained with the one-stage assay shorter than expected on the basis of the factor VIII ...
If you have aHUS, your doctor will need to monitor you closely for at least 12 months after stopping treatment for signs of worsening aHUS or problems related to a type of abnormal clotting and breakdown of your red blood cells called thrombotic microangiopathy (TMA). Symptoms or problems tha...
clotting f'scoagulation factors. C3 nephritic factor(C3 NeF) an autoantibody that stabilizes the alternativecomplementpathway C3 convertase, preventing its inactivation byfactor h, resulting in complete consumption of plasma C3; it is found in the serum of many patients with type IImembranoproliferati...
The clotting cascade is activated in three ways: (i) promoting the activation of platelets, (ii) promoting the activation of clotting factors, and (iii) promoting the aggregation and adhesion of platelets and red blood cells. For example, the positive charges of chitosan (CS) attract red ...
Although the majority of factor VII (FVII) circulates in the zymogen form, low levels of activated factor VII (FVIIa) have been postulated to exist in plasma and to serve a priming function for triggering of the clotting cascade. However, direct measurement of plasma FVIIa has not previously...
ABBR: CSF-1 A protein in human serum that promotes monocyte differentiation. SEE:granulocyte-macrophage colony-stimulating factor contact factor contact factor contact factor Coagulation factor XII, prekallikrein, and high-molecular weight kininogen: three substances that activate blood clotting. ...
clotting cascade13. Direct FXa inhibitors (rivaroxaban, apixaban, edoxaban, and betrixaban), as well as an indirect inhibitor (fondaparinux), have been developed as clinical anticoagulants14, and several direct inhibitors are currently being evaluated for use in patients at high-risk for COVID-1915...
Any of the factors involved in blood clotting. The generally accepted terms for the factors and their Roman numeral designations are as follows: factor I, fibrinogen; factor II, prothrombin; factor III, thromboplastin; factor IV, calcium (ions); factor V, proaccelerin; factor VII, serum proth...
The proteins involved in the clotting cascade, including, e.g., Factor VII, Factor VIII, Factor IX, Factor X, and Protein C, are proving to be useful therapeutic agents to treat a variety of pathological conditions. Accordingly, there is an increasing need for formulations comprising these pro...
certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising the proteins or vectors and related methods of inducing blood clotting...