Homozygous factor V Leiden mutationThoracic angioscanPulmonary embolism is a frequent and potentially serious pathology.The etiological assessment of pulmonary embolism is not carried out in a systematic way which makes the management not optimal with the possibility of repeated pulmonary embolism.Long-...
OBJECTIVE: To assess the rate of early (first trimester) and late (second and third trimester) fetal loss in women who are factor V Leiden homozygous. METHODS: Between December 1995 and February 2007, consecutive, unrelated white women who were factor V Leiden homozygous and who had been pregn...
The most common forms of familial thrombophilia are factor V Leiden (FVL) and prothrombin mutation (PTM). Homozygous FVL and PTM have long been feared conditions thought to cause high rates of morbidity and mortality. To analyse clinical features in patients with homozygous FVL and PTM, as well...
Primary Budd–Chiari syndrome in a 3-year-old boy with homozygous factor V Leiden G1691A mutation Budd鈥揅hiari syndrome (BCS) is an uncommon disorder characterized by obstruction of hepatic venous outflow. The primary BCS is a rare disease with an inci... A Boskovic,I Kitic,I Stankovic…...
It is unknown whether the homozygous state confers a higher risk than the heterozygous state. We have estimated the risk of thrombosis and the clinical features of patients who were homozygous for factor V Leiden. These patients were identified in a large, population-based, case-control study on...
Factor V Leiden refers to the c.1691G>A variant in the FV gene, which encodes coagulation factor V. This variant results in resistance to factor V protein degradation by activated protein C and increases the risk of VTE 6 to 8 fold in heterozygous carriers and 80 fold in homozygous carrier...
factor V LeidenBudd-Chiari syndromeComment on Br J Haematol. 1998 Sep;102(4):929-31.doi:10.1046/j.1365-2141.1999.01487.xGurjeewan GarewalReena DasYogesh ChawlaR K DhimanBlackwell Science LtdBritish Journal of HaematologyGarewal G,,Das R,Chawla Y.Budd-Chiari syndrome associated with homozygous ...
Factor V Leiden homozygous genotype and pregnancy outcomes. Obstet Gynecol 2009;114: 1249 –1253. 78. Prandoni P, Lensing AW, Cogo A, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 1996;125:1–7. 79. Christiansen SC, Cannegieter SC, Koster T, ...
Kyung A. Kang
Phenotypic homozygous activated protein C resistance associated with compound heterozygosity for Arg506Gln (factor V Leiden) and His1299Arg substitutions in factor V. Br J Haematol 1997; 99: 257–261. Article CAS Google Scholar Luddington R, Jackson A, Pannerselvam S, Brown K, Baglin T . ...