Study Outcomes Parkinson disease was defined as at least 2 claims for PD (ICD-9 code, G20; and ICD-10 code, 332.0) and at least 1 prescription claim for therapy associated with PD. We defined PD therapy as levodopa, carbidopa, or the carbidopa-levodopa combination; amantadine; dopamine ago...
EML4-ALK (K589M) was cloned by single point mutation encoded on the primer78,79. Constructs for generation of stable cell lines were cloned into pHR lentiviral or CLPIT retroviral plasmid backbones. For optogenetic control of FGFR signaling31, the FGFR intracellular domain with an N-terminal ...
and similar mutations have been recently reported in few very-early-onset inflammatory bowel disease (IBD) patients without CH. IfDUOX2variants indeed increase susceptibility for IBD, the enrichment ofDUOX2mutation carriers among CH patients should be reflected...
A site sphere radius of 10 Å was set to assign the binding pocket. Computer-assisted virtual mutation Computer-assisted virtual mutation was used to select mutations to improve the binding affinity of Cra for FBP. The amino acid residues at the active site were replaced with 17 common amino...
(ICD) to the nucleus where it inhibits myocardin-induced SMC gene expression.29Angiotensin II stimulation, as well as activation of L-type voltage-gated Ca2+channels, activates SMC marker genes by inducing myocardin expression and, in the case of Ang II, increasing SRF binding to CArG element...
Mutation or deletions in Smad genes can also be an important factor during tumor development. Most commonly mutations are seen on Smad4 and Smad2, due to allelic loss or LOH that has been demonstrated in up to 60% of CRCs. Mutations in Smad4 gene (16–25%) and Smad2 gene (6%) have ...
A very recent report demonstrated that the ARID1A gene mutation, which is closely associated with the malignancy of CCC cells, results in downregulation of the mevalonate pathway responsible for cholesterol biosynthesis [111]. This experimental evidence raises the possibility that TF on the...
Four potential CPD sequences as well as the nuclear localization sequence (NLS), DNA-binding domain, intramolecular chaperone domain (ICD), and transmembrane domain (TM) are shown. The second CPD sequence is fully conserved among the indicated vertebrate species. B, effects of CPD mutation on ...
Cra mutation affects the expression and activity of genes and enzymes involved in succinate biosynthesis. To examine the gene expression profiles of the mutants, the mRNA transcripts from eleven genes were analyzed using semi-quantitative RT-qPCR (Fig. 2). The 11 genes, including pfkB (...
A. Aphid thermal tolerance is governed by a point mutation in bacterial symbionts. PLoS Biol 5, e96 (2007). 33. Neriya, Y. et al. Onion yellow phytoplasma P38 protein plays a role in adhesion to the hosts. FEMS microbiol lett 361, 115–122 (2014). 34. Suzuki, S. et al. ...