Factor H binding protein (fHbp) is a key virulence factor of Neisseria meningitidis and a main component of the two licensed vaccines against serogroup B meningococcus (Bexsero and Trumenba). fHbp is a surface-exposed lipoprotein that enables the bacterium to survive in human blood by binding...
Neisseria cinerea Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines Here, we show that the commensal speciesNeisseria cinereaexpresses functional fHbp on its surface and that it is responsible for recruitment of CFH by the... H...
Fhb, a Novel Factor H-Binding Surface Protein, Contributes to the Antiphagocytic Ability and Virulence of Streptococcus suisdoi:10.1128/IAI.06294-11... - 《Infection & Immunity》 被引量: 0发表: 2012年 Significant contribution of the pgdA gene to the virulence of Streptococcus suis Streptococcus ...
Mouse anti Human Complement Factor H antibody, clone OX-24 recognizes the human serum complement protein factor H (155 kDa), binding to a different epitope from MRC OX23. 靶标信息 Factor H is a serum protein acting as an inhibitor in the complement activation system. I activates t...
组织源性原代细胞Many types of cells包装:5 × 105方(1ml)/1ml阿西美辛(标准品)质量规格:HPLC>98%,标准品Acemetacin Fibroblast growth factor-binding protein 1 ELISA KitECV304细胞,人脐内皮细胞株 人小细胞细胞,NCI-H345细胞CL-0403NCI-H524(人非小细胞细胞)5×106cells/瓶×2硬脂醇,英文名或英文缩...
We isolated streptococcal strains from tonsils removed from patients with tonsillar disease (n = 202) and studied their ability to bind the complement regulators factor H (FH) and C4b binding protein (C4BP) using 125I-labeled proteins. Blood isolates of GAS (n = 10) were obtained from ...
产品名称:Insulin-like growth factor-binding protein 2 ELISA Kit 检测范围:78-5000 pg/mL 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 选型: 产品规格:96T/48T 96T指可以做94个标本-2个标准对照-84个样本 48T指可以做47个标本-1个标准对照-42个样...
In addition to mutations in complement regulators, factor H (FH)-specific autoantibodies have been reported for aHUS patients. The aim of the present study was to understand the role of these autoantibodies in aHUS. First, the binding sites of FH autoantibodies from 5......
In AD, there is no change in CRF-BP, so the total amount of hCRF does provide a readout of free levels of CRF. Therefore, releasing CRF from its binding protein would elevate the levels of available CRF in the aging brain. Consequently, CRF-BP ligands could potentially be sufficient to...
FHR-1 is a dimeric protein circulating in plasma with functions within and independent of the complement cascade. FHR-1 binding to C3b competes with factor H binding to C3b, reducing the inhibitory activities of factor H through a process called deregulation11,12. Moreover FHR-1 was shown to...