TheNetherlands4Towhomcorrespondenceshouldbeaddressedat:DepartmentofObstetrics,GynaecologyandReproductiveMedicine,LeidenUniversityMedicalCenter,Postbus9600,2300RCLeiden,TheNetherlands.E-mail:frederique@vandunne.tkBACKGROUND:FactorVLeiden(FVL,Arg506Gln)mutationmayfacilitateembryoimplantationandincreasefertilityandfecundity....
P45 Factor V Leiden mutation and pregnancy complicationsdoi:10.1016/S0049-3848(09)70090-8U.KjellbergandM.vanRooijenandK.BremmeandSDOSThrombosis Research
BACKGROUND: Factor V Leiden mutation (Arg506Gln) increases the likelihood of venous thrombosis; it may also have a positive effect through facilitation of embryo implantation. This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester...
HH Van Boven,PH Reitsma,FR Rosendaal,... - 《Blood Coagulation & Fibrinolysis》 被引量: 238发表: 1995年 Factor V Leiden Gene Mutation and Thrombin Generation in Relation to the Development of Acute Stroke To determine the prevalence of the factor V Leiden gene mutation in relation to the ...
The objective of the study was to determine the prevalence of the factor V Leiden (FVL) mutation and its association with obstetric complications, blood loss during delivery, and venous thromboembolism (VTE). Study Design This was a prospective, observational, case-cohort study of 491 FVL carriers...
Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89: 2817–2821. CAS PubMed Google Scholar van de Water NS, French JK, Lund M, Hyde TA, White HD, Browett PJ . Prevalence of factor V Leiden and prothrombin variant F202...
217 The factor V Leiden mutation associated with APC resistance results in the continued activation of thrombin in the prothrombinase complex. Although a significant association has been established between the incidence of venous thrombosis and the factor V Leiden mutation, the influence of this ...
Factor V基因上的鸟嘌呤G突变为腺嘌呤A,造成第506上的谷氨酰胺被精氨酸替代,这样就形成了突变基因Factor V Leiden(FVL)。FVL会使凝血酶蛋白C(APC)的活性作用遭到抵抗,从而使血液的凝血功能异常,血栓形成倾向和高凝状态[6-7]。在对神经痛诱发的下颌齿槽骨坏死病例分析中,发现FVL突变率在患者中(24%)远远高于健康...
Leiden heterogeneous Buunk\ semiheterogeneous University of Groningen Van der Zee "0#\ cancer patients University of Groningen Van der Zee "1#\ control group University of Groningen Boter "0#\ students of music\ University of Utrecht theatre and _lm Boter "1#\ theatre visitors University of ...
Mechanism and pathophysiology of activated protein C-related factor V leiden in venous thrombosis Mohd,Yusuf,Ashish,... - 《Asian Journal of Transfusion Science》 被引量: 4发表: 2012年 Thrombosis in inflammatory bowel disease: clinical setting, procoagulant profile and factor V Leiden. Patients ...